Deciphering the evolution of metallo-β-lactamases: a journey from the test tube to the bacterial periplasm.
TLDR
In this paper , the evolutionary traits acquired by different clinical variants of MBLs in conditions mimicking their native environment (the bacterial periplasm) and considering whether they are soluble or membrane-bound proteins are discussed.About:
This article is published in Journal of Biological Chemistry.The article was published on 2022-02-01 and is currently open access. It has received 13 citations till now. The article focuses on the topics: Medicine & Periplasmic space.read more
Citations
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Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery.
TL;DR: This article reviewed the classification, structures, substrate profiles, and inhibition mechanisms of metallo-β-lactamases, highlighting current clinical problems due to MBL-mediated resistance and progress in understanding and combating MBL mediated resistance.
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Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function.
TL;DR: A review on gene and protein evolution relevant for better understanding metal ion biology and its role in metabolism can be found in this article , where the authors highlight the importance of analysing the origin and evolution of enzyme catalysis in the context of catalytically relevant metal ions.
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Evaluation of novel immunological rapid test (K.N.I.V.O. Detection K-Set) for rapid detection of carbapenemase producers in multidrug-resistant gram negatives.
TL;DR: The K.N.I.V.O Detection K-Set (K-Set) as discussed by the authors is a novel immunochromatographic test for detection of the 5 major carbapenemases (KPC, NDM, IMP, VIM, and OXA-48-like).
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Small-molecule inhibitors of bacterial-producing metallo-β-lactamases: insights into their resistance mechanisms and biochemical analyses of their activities.
TL;DR: In this paper , a review of metallo-β-lactamases (MBLs) and small-molecule inhibitors for AR is presented, which represents a model for future translational studies towards the discovery of effective therapeutics to overcome the challenges of AR.
References
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Journal ArticleDOI
Molecular mechanisms that confer antibacterial drug resistance
TL;DR: The authors live in an era when antibiotic resistance has spread at an alarming rate and dire predictions concerning the lack of effective antibacterial drugs occur with increasing frequency, so it is apposite to ask a few simple questions about these life-saving molecules.
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Understanding the mechanisms and drivers of antimicrobial resistance
Alison Holmes,Luke S. P. Moore,Arnfinn Sundsfjord,Arnfinn Sundsfjord,Martin Steinbakk,Sadie Regmi,Abhilasha Karkey,Philippe J Guerin,Laura J. V. Piddock +8 more
TL;DR: In this paper, the authors proposed a framework to combat the threat to human health and biosecurity from antimicrobial resistance, an understanding of its mechanisms and drivers is needed.
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Metallo-β-Lactamases: the Quiet before the Storm?
TL;DR: Their rapid dissemination is worrisome and necessitates the implementation of not just surveillance studies but also metallo-β-lactamase inhibitor studies securing the longevity of important anti-infectives.
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Darwinian evolution can follow only very few mutational paths to fitter proteins.
TL;DR: It is demonstrated that 102 mutational trajectories linking β-lactamase alleles are inaccessible to Darwinian selection and that many of the remaining trajectories have negligible probabilities of realization, which implies that the protein tape of life may be largely reproducible and even predictable.
Journal ArticleDOI
Nutritional immunity: transition metals at the pathogen-host interface.
M. Indriati Hood,Eric P. Skaar +1 more
TL;DR: This Review discusses established and emerging paradigms in nutrient metal homeostasis at the pathogen–host interface and investigates both the essentiality and toxicity of transition metals in biological systems.
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