Journal ArticleDOI
Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer’s disease☆
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TLDR
The findings raise the question of the potential implication of apoAI in the etiopathology of AD and bring serum apo AI concentration to the fore as an important biochemical marker.About:
This article is published in Neurobiology of Aging.The article was published on 2000-01-01. It has received 238 citations till now. The article focuses on the topics: Apolipoprotein B.read more
Citations
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Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease
Ian Martins,Eugene Hone,Eugene Hone,Jonathan K. Foster,Jonathan K. Foster,Susanna Sunram-Lea,Anastazija Gnjec,Stephanie J. Fuller,Stephanie J. Fuller,David Nolan,Sam Gandy,Sam Gandy,Ralph N. Martins,Ralph N. Martins +13 more
TL;DR: It can be seen that abnormal lipid, cholesterol and glucose metabolism are consistently indicated as central in the pathophysiology, and possibly the pathogenesis of AD.
Journal ArticleDOI
Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease.
TL;DR: The study shows that several glycoproteins are altered in AD, and one of the identified proteins, alpha-2-HS glycoprotein, has not previously been linked to AD.
Journal ArticleDOI
Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease
Vincenza Frisardi,Vincenzo Solfrizzi,Davide Seripa,Cristiano Capurso,Andrea Santamato,Daniele Sancarlo,Gianluigi Vendemiale,Alberto Pilotto,Francesco Panza +8 more
TL;DR: The role of these factors in the development of cognitive decline and dementia, including underlying mechanisms, supporting their influence on β-amyloid peptide metabolism and tau protein hyperphosphorylation, the principal neuropathological hallmarks of AD are discussed.
Journal ArticleDOI
Persistent, long-term cerebral white matter changes after sports-related repetitive head impacts
Jeffrey J. Bazarian,Tong Zhu,Jianhui Zhong,Damir Janigro,Eric Rozen,Andrew Roberts,Hannah Javien,Kian Merchant-Borna,Beau Abar,Eric G. Blackman +9 more
TL;DR: A single football season of RHIs without clinically-evident concussion resulted in WM changes that correlated with multiple helmet impact measures and persisted following 6 months of no-contact rest, which could potentially contribute to cumulative WM changes with subsequent RHI exposures.
The Honolulu-Asia Aging Study
Jane S. Saczynski,Lon R. White,Rita Peila,Beatriz L. Rodriguez,Lenore J. Launer,John A. Burns +5 more
TL;DR: Results raise the possibility that different lipoprotein components of cholesterol may be differentially associated with dementia, and demonstrate an inverse relation between ApoA-I and cardiovascular disease, and extend these findings to the risk of dementia.
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
A simple salting out procedure for extracting DNA from human nucleated cells
TL;DR: A rapid, safe and inexpensive method was developed to simplify the deprotein-ization procedure that yielded quantities comparable to those obtained from phenol-chloroform extractions, rendering the entire process of RFLP analysis free of toxic materials.
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Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
James E. Hixson,D. T. Vernier +1 more
TL;DR: This work has used restriction isotyping (restriction enzyme isoform genotyping) for rapid typing of common apolipoprotein E isoforms (E2, E3, E4) and distinguished each of the isoforms by a unique combination of HhaI fragment sizes that enabled unambiguous typing of all homozygotic and heterozygotic combinations.
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Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.
TL;DR: The expression of apolipoprotein E,E(LDL) receptors by brain cells and the presence of apoE- and apoA-I-containing lipoproteins in CSF suggest that the central nervous system has a mechanism for lipid transport and cholesterol homeostasis similar to that of other tissues.