Deep brain stimulation in the globus pallidus externa promotes sleep.
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TLDR
It is found that unilateral DBS in the GPe in rats significantly increased both non-rapid eye movement and rapid eye movement sleep compared to sham DBS stimulation, and the G Pe is potentially a better site for DBS to treat both insomnia and motor disorders caused by basal ganglia dysfunction.About:
This article is published in Neuroscience.The article was published on 2016-05-13 and is currently open access. It has received 38 citations till now. The article focuses on the topics: Non-rapid eye movement sleep & Neuroscience of sleep.read more
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Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review.
TL;DR: Of the studies examining the role of DBS in sleep-wake disturbances, the effect of subthalamic nucleus stimulation is most widely studied and has shown improvement in sleep quality, sleep efficiency, and sleep duration, while studies investigating changes in sleep with stimulation of thalamus, globus pallidus interna, and pedunculopontine nucleus are limited.
Journal ArticleDOI
Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington’s Disease
Daniel S. Whittaker,Dawn H. Loh,Huei-Bin Wang,Yu Tahara,Dika Kuljis,Tamara Cutler,Cristina A. Ghiani,Shigenobu Shibata,Gene D. Block,Christopher S. Colwell +9 more
TL;DR: This study demonstrates the therapeutic potential of circadian-based treatment strategies in a preclinical model of HD by exhibiting improved motor performance compared with untreated BACHD controls, and the motor improvements were correlated with improved circadian output.
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Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.
TL;DR: In this paper, the authors summarize the main findings on the composition, connectivity and functionality of different globus pallidus externa (GPe) cell populations and the potential GPe-related mechanisms of Parkinson's disease.
Journal ArticleDOI
The Neurophysiology of Sleep in Parkinson's Disease.
Hengameh Zahed,José Rafael P. Zuzuárregui,Roee Gilron,Timothy J. Denison,Philip A. Starr,Simon Little +5 more
TL;DR: In this paper, the authors reviewed cortical and sub-cortical recording studies of sleep in Parkinson's disease with a particular focus on dissecting reported electrophysiological changes and discussed the potential for targeting sleep via stimulation therapy to modify PDrelated motor and non-motor symptoms.
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The subthalamic corticotropin-releasing hormone neurons mediate adaptive REM-sleep responses to threat
Yu-Ting Tseng,B. Zhao,Shanping Chen,Jialin Ye,Jingjing Liu,Lisha Liang,Hui Ding,Bernhard Schaefke,Qingning Yang,Lina Wang,Feng Wang,Liping Wang +11 more
TL;DR: In this paper , the authors identify neurons in the medial subthalamic nucleus (mSTN) expressing corticotropin-releasing hormone (CRH) that mediate arousal and defensive responses to acute predator threats received through multiple sensory modalities across REM sleep and wakefulness.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Stimulation of the Subthalamic Nucleus Changes the Firing Pattern of Pallidal Neurons
TL;DR: Results indicate that activation of the STN efferent fibers and resultant changes in the temporal firing pattern of neurons in GPe and GPi underlie the beneficial effect of HFS in the STn in Parkinson's disease and further support the role of temporal firing patterns in the basal ganglia in the development of Parkinson’s disease and other movement disorders.
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Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep.
TL;DR: Two experiments delineate distinct preoptic sites with primary effects on the regulation of NREM sleep, REM sleep, and body temperature in rats, suggesting that they may be a necessary part of the brain circuitry that produces sleep.
Journal ArticleDOI
Reassessment of the structural basis of the ascending arousal system.
TL;DR: In rats the reticulo‐thalamo‐cortical pathway may play a very limited role in behavioral or electrocortical arousal, whereas the projection from the parabrachial nucleus and precoeruleus region, relayed by the basal forebrain to the cerebral cortex, may be critical for this process.
Journal ArticleDOI
Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation.
TL;DR: Some non-motor symptoms improve after DBS, partly because of motor benefit or reduction of drug treatment, and partly as a direct effect of stimulation.