Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis
Vicente Arroyo,Pere Ginès,Alexander L. Gerbes,F J Dudley,Paolo Gentilini,Giacomo Laffi,Telfer B. Reynolds,H. Ring-Larsen,J Schölmerich +8 more
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This article is published in Hepatology.The article was published on 1996-01-01 and is currently open access. It has received 1530 citations till now. The article focuses on the topics: Hepatorenal syndrome & Cirrhosis.read more
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Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.
TL;DR: A 2-day consensus conference on acute renal failure (ARF) in critically ill patients was organized by ADQI as discussed by the authors, where the authors sought to review the available evidence, make recommendations and delineate key questions for future studies.
Journal ArticleDOI
A model to predict survival in patients with end‐stage liver disease
Patrick S. Kamath,Russell H. Wiesner,Michael Malinchoc,Walter K. Kremers,Terry M. Therneau,Catherine L. Kosberg,Gennaro D'Amico,E. Rolland Dickson,M.B.A. W. Ray Kim M.D. +8 more
TL;DR: The MELD scale is a reliable measure of mortality risk in patients with end‐stage liver disease and suitable for use as a disease severity index to determine organ allocation priorities in patient groups with a broader range of disease severity and etiology.
Journal ArticleDOI
A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts.
Michael Malinchoc,Patrick S. Kamath,Fredric D. Gordon,Craig J. Peine,Jeffrey M. Rank,Pieter C.J. ter Borg +5 more
TL;DR: This Mayo TIPS model may predict early death following elective TIPS for either prevention of variceal rebleeding or for treatment of refractory ascites, superior to both the Child‐Pugh classification and the Child-Pugh score in predicting survival.
Journal ArticleDOI
Acute kidney injury
TL;DR: Evidence suggests that patients who have had acute kidney injury are at increased risk of subsequent chronic kidney disease, and new diagnostic techniques (eg, renal biomarkers) might help with early diagnosis.
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EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
Paolo Angeli,Mauro Bernardi,Càndid Villanueva,Claire Francoz,Rajeshwar P. Mookerjee,Jonel Trebicka,Aleksander Krag,Wim Laleman,Pere Ginès +8 more
TL;DR: The panel of experts, having emphasised the importance of initiating aetiologic treatment for any degree of hepatic disease at the earliest possible stage, extended its work to all the complications of cirrhosis which had not been covered by the European Association for the Study of the Liver guidelines.
References
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Nitric oxide: physiology, pathophysiology, and pharmacology
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Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis.
TL;DR: The stimulation of the renin‐angiotensin‐aldosterone system, vasopressin release and sympathetic nervous system associated with cirrhosis is not consonant with primary volume expansion, and favors the “overflow” hypothesis.
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Membranoproliferative glomerulonephritis associated with hepatitis C virus infection
Richard J. Johnson,David R. Gretch,Hideaki Yamabe,Jaime Hart,Carlos E. Bacchi,Peter Hartwell,William G. Couser,Lawrence Corey,Mark H. Wener,Charles E. Alpers,Richard A. Willson +10 more
TL;DR: An association between hepatitis C virus infection and membranoproliferative glomerulonephritis and the usefulness of interferon-alpha for treatment is confirmed and an improvement in renal histology is revealed.
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Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites
Angels Ginès,Angels Escorsell,Pere Ginès,Joan Saló,Wladimiro Jiménez,Luis Inglada,Miquel Navasa,Joan Clària,Antoni Rimola,Vicente Arroyo,Joan Rodés +10 more
TL;DR: The hepatorenal syndrome is a relatively frequent complication in cirrhotic patients with ascites that is associated with an extremely short survival and Liver size, plasma renin activity, and serum sodium concentration are predictors of hepatorenAL syndrome occurrence in these patients.
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Hyperdynamic circulation in cirrhosis: a role for nitric oxide?
TL;DR: Studies in animals indicate that bacterial endotoxin and cytokines induce NO synthase expression in vessel walls, with sustained NO release and consequent hypotension, which may account for the associated haemodynamic changes in cirrhosis.