Journal ArticleDOI
Dehydration-Rehydration Vesicles: A Simple Method for High Yield Drug Entrapment in Liposomes
TLDR
A novel method of liposome preparation has been developed which is simple to use, employs mild conditions and is capable of efficient entrapment of a wide range of materials.Abstract:
A novel method of liposome preparation has been developed which is simple to use, employs mild conditions and is capable of efficient entrapment of a wide range of materials. Conditions have been established to allow optimum levels of entrapment; typically 40–50% for the protocols used here, though this can be increased by using additional lipid. The procedure is based on induction of fusion of preformed vesicles by means of dehydration and controlled rehydration. Preliminary evidence suggests that the liposomes are primarily oligo and multilamellar. Scale-up of the procedure for industrial use is expected to be straightforward.read more
Citations
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Journal ArticleDOI
Liposomes as nanomedical devices
TL;DR: This review briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization, and describes some strategies developed to overcome limitations of the “first-generation” liposome-based drugs on the market and in clinical trials.
Journal ArticleDOI
Microencapsulation: industrial appraisal of existing technologies and trends
TL;DR: In this paper, a timely and targeted release of food ingredients at the right place and the right time is provided by microencapsulation, which can improve the effectiveness of food additives, broaden the application range of ingredients and ensure optimal dosage, thereby improving cost effectiveness for the food manufacturer.
Journal ArticleDOI
Non-ionic surfactant based vesicles (niosomes) in drug delivery
Ijeoma F. Uchegbu,Suresh P. Vyas +1 more
TL;DR: A summary of the achievements in the field to date of non-ionic surfactant vesicles (niosomes) as immunological adjuvants, anti-cancer/anti-infective drug targeting agents and carriers of anti-inflammatory drugs is presented.
Journal ArticleDOI
Enzymes inside lipid vesicles: preparation, reactivity and applications.
Peter Walde,Sosaku Ichikawa +1 more
TL;DR: There are a number of methods that can be used for the preparation of enzyme-containing lipid vesicles (liposomes) which are lipid dispersions that contain water-soluble enzymes in the trapped aqueous space, and a review of these studies is given and some of the main results are summarized.
Journal ArticleDOI
Liposomes and niosomes as topical drug carriers: dermal and transdermal drug delivery
Hans Schreier,Joke A. Bouwstra +1 more
TL;DR: It is concluded that liposomes and niosomes may become a useful dosage form for a variety of dermally active compounds, specifically due to their ability to modulate drug transfer and serve as nontoxic penetration enhancers.
References
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Journal ArticleDOI
Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids
TL;DR: It is found that as the surface charge of the lipid lamellae is increased, the amount of cation per μmle of lipid increases, and the phospholipid liquid crystalline structures appear to “bind” or “capture” cations.
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Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation
TL;DR: A substantial fraction of the aqueous phase is entrapped within the vesicles, encapsulating even large macromolecular assemblies with high efficiency, and has unique advantages for encapsulating valuable water-soluble materials such as drugs, proteins, nucleic acids, and other biochemical reagents.
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Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes
Fred C. Olson,C.A. Hunt,Francis C. Szoka,W.J. Vail,Demetrios Papahadjopoulos,Demetrios Papahadjopoulos +5 more
TL;DR: Liposomes of defined size and homogeneity have been prepared by sequential extrusion of the usual multilamellar vesicles through polycarbonate membranes, which can double the encapsulation efficiency of the liposome preparation.
Journal ArticleDOI
Formation and properties of thin‐walled phospholipid vesicles
John P. Reeves,Robert M. Dowben +1 more
TL;DR: Large numbers of thin‐walled vesicles, 0.5 to 10 μ in diameter, can be formed by permitting a thinly spread layer of hydrated phospholipids to swell slowly in distilled water or an aqueous solution of nonelectrolytes, making them a useful system for studying permeability.
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Large volume liposomes by an ether vaporization method
David W. Deamer,A.D. Bangham +1 more
TL;DR: Liposomes, in the size range of microsomal vesicles, are formed when ether solutions of a variety of lipids are injected into warm aqueous solutions and the volume trapping efficiency is approximately ten times that of sonicated and hand-shaken preparations.