Dengue viral infections
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TLDR
This review outlines aspects of the epidemiology of d Dengue infections, the dengue virus and its mosquito vector, clinical features and pathogenesis of denge infections, and the management and control of these infections.Abstract:
Dengue viral infections are one of the most important mosquito borne diseases in the world. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue haemorrhagic fever (DHF), or dengue shock syndrome. Annually, 100 million cases of dengue fever and half a million cases of DHF occur worldwide. Ninety percent of DHF subjects are children less than 15 years of age. At present, dengue is endemic in 112 countries in the world. No vaccine is available for preventing this disease. Early recognition and prompt initiation of appropriate treatment are vital if disease related morbidity and mortality are to be limited. This review outlines aspects of the epidemiology of dengue infections, the dengue virus and its mosquito vector, clinical features and pathogenesis of dengue infections, and the management and control of these infections.read more
Citations
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Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden.
Peter J. Hotez,Aruna Kamath +1 more
TL;DR: The overall burden of Africa's neglected tropical diseases may be severely underestimated, and a full assessment is an important step for disease control priorities, particularly in Nigeria and the Democratic Republic of Congo, where the greatest number of NTDs may occur.
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The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker.
David A. Muller,Paul R. Young +1 more
TL;DR: An overview of these somewhat disparate areas of research is provided, drawing together the wealth of data generated over more than 40 years of study of this fascinating protein, which plays an essential cofactor role in replication.
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Virtual screening for potential inhibitors of human hexokinase II for the development of anti-dengue therapeutics
TL;DR: Novel compounds are proposed, which may act as potential drugs against DENV by inhibiting HKII’s activity by using the computational studies.
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Interactions of the heart and the liver
Sören Möller,Mauro Bernardi +1 more
TL;DR: In patients with advanced cirrhosis, physical and/or pharmacological stress may reveal a reduced cardiac performance with systolic and diastolic dysfunction and electrophysical abnormalities termed cirrhotic cardiomyopathy, and no specific therapy can be recommended, but it should be supportive and directed against the heart failure.
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Dynamic epidemiological models for dengue transmission: a systematic review of structural approaches.
TL;DR: In this paper, the authors identified relevant publications using PubMed and ISI Web of Knowledge, focusing on mathematical deterministic models of dengue transmission and identified important characteristics for future model development.
References
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Journal ArticleDOI
Pathogenesis of dengue: challenges to molecular biology
TL;DR: This work has identified a severe syndrome, dengue hemorrhagic fever/dengue shock syndrome, in Southeast Asian children, which recently has also been identified in children infected with the virus in Puerto Rico.
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Dengue: an update
María G. Guzmán,Gustavo Kourí +1 more
TL;DR: The status of vaccine development is described and it is emphasised that the only alternative that the authors have today to control the disease is through control of its vector Aedes aegypti.
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Effect of temperature on the vector efficiency of Aedes aegypti for dengue 2 virus.
TL;DR: Temperature-induced variations in the vector efficiency of Ae.
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The maintenance need for water in parenteral fluid therapy
TL;DR: It is generally agreed that the maintenance requirements for water of individuals is determined by their caloric expenditure, and possible exceptions to this figure are discussed.
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High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
Daniel H. Libraty,Paul R. Young,Darren Pickering,Timothy P. Endy,Siripen Kalayanarooj,Sharone Green,David W. Vaughn,Ananda Nisalak,Francis A. Ennis,Alan L. Rothman +9 more
TL;DR: In this paper, the secreted dengue virus nonstructural protein NS1 (sNS1) was measured daily in 32 children with Dengue-2 virus infections participating in a prospective, hospital-based study.
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