Proceedings ArticleDOI
Design Optimization at the Fluid-Level Synthesis for Safe and Low-Cost Droplet-Based Microfluidic Biochips
Arpan Chakraborty,Piyali Datta,Rajat Kumar Pal +2 more
- pp 127-132
TLDR
A fluid-level design for DMFBs is proposed that is capable of handling reliability and also free from cross contamination, and a graph model has been used to tackle them.Abstract:
Droplet-based Digital Microfluidic Biochips (or DMFBs) are now being the prime platform for a number of point of care diagnostics, clinical studies, and sample preparations. Several design optimization methods exist at the fluid-level that automate the tasks of a DMFB. However, in high frequency applications, its performance heavily deteriorates in the order of degrading electrodes producing incorrect outcomes. Vague results may also be generated if cross contamination during droplet routing is not avoided. We define a DMFB to be safe if it is capable of handling reliability and also free from cross contamination. Alongside, as the fluid-level of DMFBs comprises several tasks that altogether introduces design cycles and leads to higher cost, a low-cost platform is urgently required. This paper proposes a fluid-level design for DMFBs that considers the above facts together. A graph model has been used to tackle them. An exact algorithm is presented. The obtained results are validated with several benchmarks.read more
Citations
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Proceedings ArticleDOI
Lifetime Improvement of Digital Microfluidic Biochips based on the Improved Whale Optimization Algorithm for Protein Analysis Instrument System
TL;DR: An improved whale optimization algorithm (IWOA) is proposed, which can reduce excessive use of an electrode and reuse electrodes in average manner to optimal the longest lifetime of DMFBs during the design process.
References
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Journal ArticleDOI
High-level synthesis of digital microfluidic biochips
Fei Su,Krishnendu Chakrabarty +1 more
TL;DR: This work proposes a system design methodology that attempts to apply classical high-level synthesis techniques to the design of digital microfluidic biochips and develops an optimal scheduling strategy based on integer linear programming and two heuristic techniques that scale well for large problem instances.
Journal ArticleDOI
Cross-Contamination Avoidance for Droplet Routing in Digital Microfluidic Biochips
Yang Zhao,Krishnendu Chakrabarty +1 more
TL;DR: A droplet-routing method that avoids cross-contamination in the optimization of droplet flow paths and targets disjoint droplet routes and minimizes the number of cells used for droplet routing is proposed.
Journal ArticleDOI
Algorithms for the Weight Constrained Shortest Path Problem
Irina Dumitrescu,Natashia Boland +1 more
TL;DR: In this paper, the authors considered the case of the weight constrained shortest path problem (WCSPP) defined on a graph without cycles and presented a new exact algorithm, based on scaling and rounding of weights.
Journal ArticleDOI
Design Automation and Test Solutions for Digital Microfluidic Biochips
TL;DR: This tutorial paper describes emerging computer-aided design (CAD) tools for the automated synthesis and optimization of biochips from bioassay protocols and recent advances in fluidic-operation scheduling, module placement, droplet routing, pin-constrained chip design, and testing are presented.
Journal ArticleDOI
Cross-Contamination Aware Design Methodology for Pin-Constrained Digital Microfluidic Biochips
TL;DR: This paper presents the first design automation flow that considers the cross-contamination problems on pin-constrained biochips, and proposes early crossing minimization algorithms during placement and systematic wash droplet scheduling and routing that require only one extra control pin and zero assay completion time overhead for practical bioassays.
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