Design, Preparation, and Characterization of Effective Dermal and Transdermal Lipid Nanoparticles: A Review
Dima Khater,Hamdi Nsairat,Fadwa Odeh,Mais M. Saleh,Areej M. Jaber,Walhan Alshaer,Abeer Al Bawab,Mohammad S. Mubarak +7 more
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TLDR
This review focuses on solid lipid nanoparticles (SLNs), nanostructured lipid nanocarriers (NLCs), and nanoemulsions (NEs) developed for topical and transdermal delivery of active compounds.Abstract:
Limited permeability through the stratum corneum (SC) is a major obstacle for numerous skin care products. One promising approach is to use lipid nanoparticles as they not only facilitate penetration across skin but also avoid the drawbacks of conventional skin formulations. This review focuses on solid lipid nanoparticles (SLNs), nanostructured lipid nanocarriers (NLCs), and nanoemulsions (NEs) developed for topical and transdermal delivery of active compounds. A special emphasis in this review is placed on composition, preparation, modifications, structure and characterization, mechanism of penetration, and recent application of these nanoparticles. The presented data demonstrate the potential of these nanoparticles for dermal and transdermal delivery.read more
Citations
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Journal ArticleDOI
Liposomes: structure, composition, types, and clinical applications
TL;DR: Liposomes are now considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, and low immunogenicity.
Journal ArticleDOI
Nanostructured Lipid Carrier-Mediated Transdermal Delivery of Aceclofenac Hydrogel Present an Effective Therapeutic Approach for Inflammatory Diseases.
TL;DR: In this paper, the authors developed and characterized a nanostructured lipid carrier (NLC)-based ACE (ACE-NLC) hydrogel for an efficient transdermal delivery.
Journal ArticleDOI
Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration
Jafar Akbari,Majid Saeedi,Fatemeh Ahmadi,Seyyed Mohammad Hassan Hashemi,Amir Hossein Babaei,Sadra Yaddollahi,Seyyed Sohrab Rostamkalaei,Kofi Asare-Addo,Ali Nokhodchi +8 more
TL;DR: The easy and simple scalability of novel SLNs and nano lipid carriers, along with their various processing procedures, recent developments, limitation and toxicity, formulation optimization and approaches for the manufacture of lipid nanoparticles, lyophilization and drug release are comprehensively discussed in this review.
Journal ArticleDOI
The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years.
TL;DR: In this paper, a review of topical methods for enhancing percutaneous permeation is presented, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose.
Journal ArticleDOI
An Overview on Topical Administration of Carotenoids and Coenzyme Q10 Loaded in Lipid Nanoparticles.
Luciana de Souza Guedes,Renata Miliani Martinez,Nadia Araci Bou-Chacra,Maria Valéria Robles Velasco,Catarina Rosado,André Rolim Baby +5 more
TL;DR: In this paper, the current state of the art in the encapsulation of carotenoids and coenzyme Q10 in lipid nanoparticles to improve their bioavailability, chemical stability, and skin absorption is discussed.
References
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Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
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Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems.
M. Danaei,M Dehghankhold,Sara Ataei,F Hasanzadeh Davarani,R. Javanmard,A Dokhani,Saied Nouri Khorasani,Mohammad Reza Mozafari +7 more
TL;DR: This review highlights the significance of size and PDI in the successful design, formulation and development of nanosystems for pharmaceutical, nutraceutical and other applications.
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Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
Journal ArticleDOI
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
TL;DR: As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations.
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