Showing papers in "European Journal of Pharmaceutical Sciences in 2018"

TL;DR: Despite the cutaneous use of SLN and NLC has been proposed for both local and transdermal delivery, the reported studies show promising results only for local application, so more research is required to better understanding the interaction mechanisms of lipid nanoparticles with skin lipids.

TL;DR: Chitosan‐alginate lyophilized microparticles showed the best‐controlled release of vancomycin with the average release of 22 &mgr;g per day for 14 days, and Fickian diffusion dominates the drug transport mechanism of all air‐dried samples during the study period.

TL;DR: This review aims to provide an overview on the different approaches that exploit the antimicrobial activity of chitosan‐based nanosystems and their applications, and highlight the latest advances in this field.

TL;DR: This work provides a novel example where computer‐aided design was instrumental at modifying the performance of solid dosage forms and may serve as the foundation for a new generation of dosage forms with complicated geometric structures to achieve functionality that is usually achieved by a sophisticated formulation approach.

TL;DR: The superior robustness of cell-free barriers makes them suitable for the combined dissolution/permeation evaluation of formulations and they can also be used to evaluate non-oral drug delivery by adjusting the composition of the membrane.

TL;DR: Results demonstrated that 3D printing is a highly adjustable and digitally controllable technology that can be applied to produce release‐tailored medications.

TL;DR: The results from the current study emphasize the potentiality of 3D printing technology for tailor‐made solid dosage forms for combined pharmacotherapy, even at the cases when API's with different desirable release profiles are employed.

TL;DR: The present investigation paved a new way for implementing the modified coaxial processes, which can be utilized to fabricate structural nanocomposites with ultra‐thin shells for enhancing the fast dissolution of poorly water‐soluble drugs.

TL;DR: This review highlights the most recent advances (mainly in the last five years) of patches aimed for transdermal drug delivery, focusing on the different materials (natural, synthetic and blends) and latest designs for the development of such devices, emphasizing also their combination with drug carriers that enable enhanced drug solubility and a more controlled release of the drug over the time.

TL;DR: This integrative review attempts to identify the promising pharmacophore that serves as dual inhibitors of COX‐2/5‐LOX enzymes with improved safety profile.

TL;DR: Uptake studies showed that fluorescent mannosylated SLN (M‐SLN) were more efficient in be internalized comparatively to SLN, demonstrating the receptor‐dependence internalization of functionalized SLN.

TL;DR: Owing to its low cost and versatility, this approach can be adapted to wide spectrum of liquid formulations such as small and large molecule solutions and obviate the need for compatibility with the high temperature of FDM 3D printing process.

TL;DR: Flexible dose combinations of two anti‐hypertensive drugs in a single bilayer tablet with a range of doses were fabricated using dual fused deposition modelling (FDM) 3D printer, offering an optimal clinical solution to hypertension therapy in a patient‐centric healthcare service.

TL;DR: The cytotoxicity test was performed against MCF‐7 breast cancer cell line to check the anticancer property of the hybrid nano carrier with the curcumin drug and the drug release profiles showed the best fit with Higuchi model under the most of conditions.

TL;DR: Increased biocompatibility, site‐specific delivery based on various ligands, enhanced transfection efficiency, sustained and controlled release behavior based on stimuli responsiveness are benefits of functionalized dendrimer which are discussed in this review.

TL;DR: Ocular absorption does not increase proportionally with the increasing corneal drug permeability, because loss of drug across the conjunctiva to the blood circulation restricts significantly ocular drug bioavailability and, therefore, ocular absorption doesn't increase proportionately with the increase in permeability.

TL;DR: Investigation of pharmacopeia properties of pH, sedimentation volume and swelling capacity revealed the suitability of the raw and purified samples for pharmaceutical and cosmetic applications and the microbiological tests indicated that the samples free from harmful microbial pathogens.

TL;DR: 3D structure of the drug loaded complex film was analyzed by Micro‐CT imaging and it was showed that using this method would be very advantageous for further studies about the investigation of complexation than the other imaging methods in order to determine the volume and the size of the formed complexes within the structure at the same time.

TL;DR: This review explores the evolution of fu terms included when implementing IVIVE, the concept of protein‐facilitated uptake, and the mechanisms that have been proposed to account for facilitated uptake.

TL;DR: This study successfully formulated personalised warfarin ODFs using a modified TIJ printer, widening the range of applications for TIJ printing to formulate narrow therapeutic index drugs.

TL;DR: In vitro testing demonstrated that the MSN‐LA delivery system could not only induce S cell cycle arrest, enhance the cytotoxicity and improve the tumor target of SO and siVEGF, but also enhance theSiVEGF transfection efficiency in ASGPR‐overexpressing Huh7 cells.

TL;DR: F folate targeted liposomes provided an effective and safe strategy for colon cancer targeted chemotherapy and showed better tumor inhibition than free drug, it can be concluded.

TL;DR: The human CNS PBPK model could successfully predict their concentration‐time profiles in multiple human CNS compartments in physiological CNS conditions within a 1.6‐fold error and supports the relevance of the developed model to allow more effective selection of CNS drug candidates.

TL;DR: In vitro skin permeation studies revealed that the percentage of total acyclovir loading which permeated the skin over a 24 h period using MNs was approximately 45 times higher than that of a commercial cream formulation (Lipsore®), and acy Clovir‐loaded dissolving MN arrays could be a promising approach for effective local delivery of acyClovir.

TL;DR: The prepared DDS appeared to be a promising candidate for brain cancer treatment and a favorable MRI contrast agent, especially in respect of free LA‐CUR.

TL;DR: Maleimide‐functionalised PEGylated Liposomes (PEG‐Mal) were explored as mucoadhesive vehicles for drug delivery to the urinary bladder and were found to be more mucosa‐penetrating compared to other liposomes.

TL;DR: The nanofiber formation was confirmed, and the wound healing potential of the nanofibers was tested in externally induced excisional wounds in male diabetic db/db mice, indicating the potential of &bgr;G‐nan ofibers as wound dressing.

TL;DR: The results showed that the structural properties of nanofiber mat are crucial in particular drug‐polymer combinations, affecting the drug release and consequently the antibacterial activity.

TL;DR: Antibacterial activity against Propionibacterium acnes showed that adapalene loaded nano‐emulsion is effective in reducing minimum inhibitory concentration of the formulation in comparison with tea tree oil nano-emulsion, and pure Tea tree oil.

TL;DR: Different approaches for testing the drug release from nanoparticles in the fields of formulation development and quality control will be discussed, to improve the prediction of in vivo performance and clinical outcomes.