Journal ArticleDOI
Design, synthesis and anti-microbial activity of 1H-pyrazole carboxylates.
Radhakrishnan Sridhar,Paramasivam T. Perumal,S. Etti,G. Shanmugam,M. N. Ponnuswamy,Vaiyapuri R. Prabavathy,Narayanasamy Mathivanan +6 more
TLDR
The effect of 1H-pyrazole carboxylates on the mycelial growth of plant pathogenic fungi is revealed and the first X-ray structure in the family of microbicidal 1 H- pyrazole-4-carboxylate is presented.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2004-12-20. It has received 172 citations till now. The article focuses on the topics: Pyrazole.read more
Citations
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Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents.
TL;DR: Compound 3-(3,4-dimethylphenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide (C5) displayed the most potent EGFR inhibitory activity, which would be a potential anticancer agent.
Journal ArticleDOI
Synthesis and antiviral activity of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) against peste des petits ruminant virus (PPRV).
K. Sujatha,Gnanamani Shanthi,Nagarajan Panneer Selvam,S. Manoharan,Paramasivan T. Perumal,Melani Rajendran +5 more
TL;DR: Compound 3i emerged as the most interesting compound in this series exhibiting excellent antiviral activity against PPRV and found to be more potent than the standard drug ribavirin used.
Journal ArticleDOI
Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety
TL;DR: Results confirm that novel pyrazolyl acyl thioureas derived compounds may be utilized for cancer treatment and have a great potential and significance for further investigations.
Journal ArticleDOI
Synthetic pyrazole derivatives as growth inhibitors of some phytopathogenic fungi.
TL;DR: Among the pyrazolopyrimidines the derivative supplied with the benzylic group was the most active on the three fungi and in particular against P. ultimum, shown to be the most sensitive.
Journal ArticleDOI
Synthesis and anti-microbial activity of pyrazolylbisindoles--promising anti-fungal compounds.
Ganesabaskaran Sivaprasad,Paramasivan T. Perumal,Vaiyapuri R. Prabavathy,Narayanasamy Mathivanan +3 more
TL;DR: A series of pyrazolylbisindole derivatives have been synthesized by reacting substituted pyrazole aldehydes with substituted indoles using phosphotungstic acid, a Keggin type heteropoly acid as catalyst exhibiting excellent anti-fungal activity.
References
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ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI)
TL;DR: L Lists of software presented and~or reviewed in the Journal of Applied Crystallography are available on the World Wide Web at the above address, together with information about the availability of the software where this is known.
Book
Comprehensive Heterocyclic Chemistry II
TL;DR: In this article, the CHEC III is organized in 15 volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three and four-membered heterocycles, together with all fused systems containing a three- or four-measured heterocyclic ring.
Journal ArticleDOI
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Journal ArticleDOI
The vilsmeier-haack reaction - III Cyclization of hydrazones to pyrazoles
Journal ArticleDOI
Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists
David J. Wustrow,Thomas Capiris,Ronald Rubin,James A. Knobelsdorf,Hyacinth Akunne,M. Duff Davis,Robert G. MacKenzie,T. A. Pugsley,Kim Zoski,Thomas G. Heffner,Lawrence D. Wise +10 more
TL;DR: The 3-dimensional structure of one of the most potent analogs in this series, 10d, was determined by X-ray crystallography and suggests the spatial requirements for potent CRF-1 receptor binding affinity in thisseries of 3-phenylpyrazolo[1,5-a]pyrimidines.
Related Papers (5)
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more