Journal ArticleDOI
Detection procedures of ultrasound contrast agents.
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TLDR
Although the results of conventional second harmonic imaging are still not optimal for perfusion imaging applications, in combination with Doppler techniques it is one of the most sensitive techniques currently available in terms of agent-to-tissue ratio.About:
This article is published in Ultrasonics.The article was published on 2000-03-01. It has received 172 citations till now. The article focuses on the topics: Doppler effect & Second-harmonic imaging microscopy.read more
Citations
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Journal ArticleDOI
Molecular ultrasound imaging: current status and future directions
TL;DR: Current concepts and future directions of molecular ultrasound imaging are reviewed, including different classes of molecular ultrasounds contrast agents, ongoing technical developments of pre-clinical and clinical ultrasound systems, the potential of Molecular ultrasound for imaging different diseases at the molecular level, and the translation of molecular Ultrasound into the clinic.
Journal ArticleDOI
Ultrasound-induced encapsulated microbubble phenomena.
TL;DR: In this paper, theories that were validated for relatively big, free (not encapsulated) gas bubbles are compared with high-speed optical observations of insonified contrast agent microbubbles and it is concluded that most of the results obtained are consistent with free gas bubble theory.
Journal ArticleDOI
Optimising phase and amplitude modulation schemes for imaging microbubble contrast agents at low acoustic power.
TL;DR: Results show that established two-pulse pulse-inversion and amplitude-modulation approaches perform similarly, providing 14 +/- 1 dB of enhancement, compared with the echoes from the linear scatterer.
Journal ArticleDOI
Super harmonic imaging: a new imaging technique for improved contrast detection.
TL;DR: It is demonstrated, in this study, that the CTR increases as a function of the order of the harmonic frequency, in agreement with the calculations using existing models for the response of encapsulated bubbles and known theory of nonlinear propagation.
Journal ArticleDOI
High frequency nonlinear B-scan imaging of microbubble contrast agents
David E. Goertz,Emmanuel Cherin,Andrew Needles,Raffi Karshafian,A.S. Brown,Peter N. Burns,F.S. Foster +6 more
TL;DR: The development of nonlinear microbubble B-scan imaging instrumentation capable of operating at transmit center frequencies between 10 and 50 MHz and the successful detection of microvessels in the rabbit ear and in the mouse heart is described.
References
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Journal ArticleDOI
Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents
TL;DR: In vitro measurements comparing flowing agent and cellulose particles suggest that pulse inversion Doppler can provide 3 to 10 dB more agent to tissue contrast than harmonic imaging with similar pulses, and in vitro measurements suggest that broadband pulse inverts can provide up to 16 dB more contrast than broadband conventional Dopplers.
Journal ArticleDOI
Contrast agents in diagnostic ultrasound.
Jonathan Ophir,Kevin J. Parker +1 more
TL;DR: The mechanisms for production of backscatter contrast, as well as attenuation contrast and speed of sound contrast, and the potential advantages and disadvantages of various classes of contrast agents are explained.
Journal ArticleDOI
Pressure dependence of subharmonic signals from contrast microbubbles.
TL;DR: Preliminary results indicate that, over the pressure range of 0-186 mmHg, the subharmonic amplitude of scattered signals decreases by as much as 10 dB under optimal acoustic settings and the first and second harmonic amplitudes decrease by less than 3 dB.
Journal ArticleDOI
Advantages of Subharmonic Over Second Harmonic Backscatter for Contrast-To-Tissue Echo Enhancement
TL;DR: It is shown experimentally that backscatter from two ultrasonic contrast agents suspended in water or saline contains subharmonics of the incident frequency that are stronger than those backscattered at the same incident pressure from chicken breast.
BookDOI
Advances in echo imaging using contrast enhancement
TL;DR: This chapter discusses Contrast Enhanced Color Doppler in the Assessment of Mitral Regurgitation and its implications for clinical use, as well as the history, Basics and Safety of Contrast Agents.