Journal ArticleDOI
Development of in vitro screening system for assessment of antifilarial activity of compounds.
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TLDR
It is felt that mf stage when used in in vitro test using motility and MTT assays as parameters would be useful in primary screening of new potential filaricides.About:
This article is published in Acta Tropica.The article was published on 1998-07-30. It has received 35 citations till now. The article focuses on the topics: In vivo & Acanthocheilonema viteae.read more
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Book ChapterDOI
Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction.
TL;DR: Second generation tetrazolium dyes that form water-soluble formazans and require an intermediate electron acceptor for reduction (XTT, WST-1 and to some extent, MTS), are characterised by a net negative charge and are therefore largely cell-impermeable and considerable evidence indicates that their reduction occurs at the cell surface or at the level of the plasma membrane via trans-plasma membrane electron transport.
Journal ArticleDOI
In vitro screening of six anthelmintic plant products against larval Haemonchus contortus with a modified methyl-thiazolyl-tetrazolium reduction assay.
TL;DR: Based on results obtained with larval Haemonchus contortus, the modified MTT reduction assay could be a possible method for testing plant products with anthelmintic properties.
Journal ArticleDOI
Gedunin and photogedunin of Xylocarpus granatum possess antifilarial activity against human lymphatic filarial parasite Brugia malayi in experimental rodent host
Sweta Misra,Meenakshi Verma,Sunil Kumar Mishra,S. C. Srivastava,Vijai Lakshmi,Shailja Misra-Bhattacharya +5 more
TL;DR: The findings reveal that the extract from the fruit X. granatum contains promising in vitro and in vivo antifilarial activity against human lymphatic filarial parasite B. malayi which could be attributed to the presence of two pure compounds gedunin and photogedunin.
Journal ArticleDOI
Chemical constituents and antifilarial activity of Lantana camara against human lymphatic filariid Brugia malayi and rodent filariid Acanthocheilonema viteae maintained in rodent hosts.
Namita Misra,Mithilesh Sharma,Kanwal Raj,Anil Dangi,Sudhir Srivastava,Shailja Misra-Bhattacharya +5 more
TL;DR: The first ever report on the antifilarial efficacy of Lantana camara is reported, which was found effective against a subcutaneous rodent filariid Acanthocheilonema viteae maintained in Mastomys coucha and exerted strong microfilaricidal and sterilization efficacy with mild macrofilaricide action.
Journal ArticleDOI
Plant products in the treatment and control of filariasis and other helminth infections and assay systems for antifilarial/anthelmintic activity.
TL;DR: This review focuses on the plant products reported to be useful in the control and treatment of human helminth infections with the main emphasis on filariasis and the in vitro and in vivo systems available for assaying anthelmintic activity.
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Journal ArticleDOI
Ivermectin for the treatment of Wuchereria bancrofti filariasis. Efficacy and adverse reactions.
V Kumaraswami,Eric A. Ottesen,V. Vijayasekaran,S. Uma Devi,Mythili Swaminathan,Mohammed A. Aziz,G. R. Sarma,Ragneathi Prabhakar,Srikanth Tripathy +8 more
TL;DR: Ivermectin treatment was evaluated for efficacy and side effects in 40 patients in South India who had microfilaremia and bancroftian filariasis, and it was found to be completely effective in clearing blood microfilariae within five to 12 days.
Journal Article
The further application of MTT-formazan colorimetry to studies on filarial worm viability.
TL;DR: It is tentatively concluded that the tips of filariae, particularly the anterior ends, may well be metabolically the most active part of the worm and selective sampling of these regions for Onchocerca might therefore be a useful indicator for the viability of the parasite.
Journal Article
Studies on the causation of adverse reactions in microfilaraemic host following diethylcarbamazine therapy (Dipetalonema viteae in Mastomys natalensis).
TL;DR: It is concluded that the adverse reactions seen after DEC treatment are due to the release of biogenic amines in an anaphylactic type of reaction subsequent to massive release of parasite antigen in a sensitised host, which is directly proportional to the intensity of microfilaraemia.