Journal ArticleDOI
Dopamine antagonists induce gastric lesions in rats.
Predrag Sikiric,Juraj Geber,Dragutin Ivanović,Ernest Suchanek,Veljko Gjuriš,Milica Tućan-Foretić,Stjepan Mise,Branimir Cvitanović,Ivo Rotkvić +8 more
Reads0
Chats0
TLDR
It is concluded that the model of gastric lesions induced by dopamine antagonists could be successfully applied in further investigations of the role of dopamine in the pathogenesis of ulcer disease.About:
This article is published in European Journal of Pharmacology.The article was published on 1986-11-12. It has received 37 citations till now. The article focuses on the topics: Dopamine antagonist & Domperidone.read more
Citations
More filters
Journal ArticleDOI
Dopamine in gastrointestinal disease.
Gary B. Glavin,Sandor Szabo +1 more
TL;DR: It is suggested that dopamine is a key element of the “brain-gut axis” and represents a potentially important target for pharmacotherapeutic exploitation.
Journal ArticleDOI
A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC
Predrag Sikiric,Marijan Petek,Rudolf Rucman,Sven Seiwerth,Zeljko Grabarevic,Ivo Rotkvić,Branko Turkovic,Vjekoslav Jagić,Boris Mildner,Marko Duvnjak,Nada Lang,Z. Danilović,A. Cviko,M. Kolega,Ahmet Sallmani,S. Djačić,Miljenko Bura,Tomislav Brkić,Marko Banić,Milan Dodig,V. Corić,Velimir N. Šimičević,Marija Veljača,Damir Erceg,Damir Ježek,L.J. Simunić-Banek,N. Skroza,Krešimir Bulić,Gojko Buljat,Miroslav Hanževački,V. Orihovac,Dražen Lučinger,Josip Čulig,Jadranka Separovic,Anton Marovic,Stjepan Mise,Ernest Suchanek,Wendy Matoz,Darko Perović,Miroslav Gjurašin,S. Mikulandra,K. Derniković,V. Cuk,I. Karakas +43 more
TL;DR: BPC, as a possible endogenous free radical scavenger and organoprotection mediator, could be a useful prototype of a new class of drugs, organoprotsective agents.
Journal ArticleDOI
Beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity
Predrag Sikiric,Sven Seiwerth,Zeljko Grabarevic,Rudolf Rucman,Marijan Petek,Vjekoslav Jagić,Branko Turkovic,Ivo Rotkvić,Stjepan Mise,Ivan Zoricic,Miroslav Gjurašin,Paško Konjevoda,Jadranka Separovic,Danica Galešić Ljubanović,Branka Artuković,Mirna Bratulić,Marina Tišljar,Ljubica Jurina,Gojko Buljat,Pavle Miklić,Anton Marovic +20 more
TL;DR: Analysis of gastroprotective effect of the pentadecapeptide BPC 157 on gastric lesions produced in rats by 96% ethanol, restraint stress, and indomethacin provides evidence for complex synergistic interaction between the beneficial effectiveness of B PC 157 and peptidergic sensory afferent neuron activity.
Journal ArticleDOI
Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats.
Nikola Jelovac,Predrag Sikiric,Rudolf Rucman,Marijan Petek,Anton Marovic,Darko Perović,Sven Seiwerth,Stjepan Mise,Branko Turkovic,Goran Dodig,Pavle Miklić,Gojko Buljat,Ingrid Prkačin +12 more
TL;DR: Findings indicate that pentadecapeptide BPC 157 fully interacts with the dopamine system, both centrally and peripherally, or at least, that BPC157 interferes with some steps involved in catalepsy and/or ulcer formation.
Journal ArticleDOI
A Role for Dopamine as an Endogenous Protective Factor in the Rat Stomach
TL;DR: A role for endogenous dopamine as a mediator of the adaptive cytoprotection phenomenon is suggested, based on dose-response studies with other serotonergic and dopaminergic antagonists suggested.
References
More filters
Journal ArticleDOI
Cytoprotection by Prostaglandins in Rats Prevention of Gastric Necrosis Produced by Alcohol, HCl, NaOH, Hypertonic NaCl, and Thermal Injury
TL;DR: In this paper, the authors show that prostaglandins, by a mechanism other than the inhibition of gastric acid secretion, maintain the cellular integrity of the gastric mucosa, and might be beneficial in the treatment of a variety of diseases in which gastric injury is present.
Journal ArticleDOI
Early Vascular Injury and Increased Vascular Permeability in Gastric Mucosal Injury Caused by Ethanol in the Rat
TL;DR: It is suggested that vascular injury is an early pathogenetic factor in the development of ethanol-induced gastric hemorrhagic erosions and the degree of vascular damage, unlike the injury to surface epithelial cells, is reduced by pretreatment with prostaglandin F2 beta or the sulfhydryl cysteamine.
Journal ArticleDOI
Metoclopramide. An updated review of its pharmacological properties and clinical use.
TL;DR: Metoclopramide has been confirmed as an effective drug in treating and preventing various types of vomiting and as a useful agent in oesophageal reflux disease, gastroparesis, dyspepsia, and in a variety of functional gastrointestinal disorders.
Journal ArticleDOI
Metoclopramide: A Review of its Pharmacological Properties and Clinical Use
TL;DR: Pharmacodynamic studies in man and in a variety of experimental animals have established that metoclopramide, after oral or intravenous administration, rapidly affects the motility of the gastro-intestinal tract, and is effective in preventing apomorphine-induced vomiting in man.
Related Papers (5)
Neuroendocrine mechanisms of stress ulceration: focus on thyrotropin-releasing hormone (TRH).
Hepatoprotective effect of BPC 157, a 15-aminoacid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin
Predrag Sikiric,Sven Seiwerth,Zeljko Grabarevic,Rudolf Rucman,Marijan Petek,Ivo Rotkvić,Branko Turkovic,Vjekoslav Jagić,Boris Mildner,Marko Duvnjak,Z. Danilović,M. Kolega,Ahmet Sallmani,Sanja Dacic,Milan Dodig,Nada Lang,Jadranka Separovic,V. Corić,Velimir N. Šimičević,Krešimir Bulić,Marija Veljača,Nevena Skroza,Marko Banić,Tomislav Brkić,Gojko Buljat,Stjepan Mise,Drazen Lucinger,Miljenko Bura +27 more