Journal ArticleDOI
Dosage effects of resveratrol on ethanol-induced cell death in the human K562 cell line.
Wen-Hsiung Chan,Ying-Jing Chang +1 more
TLDR
It is shown that higher concentrations of ethanol induced a shift from apoptotic to necrotic cell death in human K562 cells, and that resveratrol, a grape-derived phytoalexin with known antioxidant and anti-inflammatory properties, inhibited or enhanced ethanol-induced apoptosis/necrosis depending on the treatment dosage.About:
This article is published in Toxicology Letters.The article was published on 2006-02-08. It has received 34 citations till now. The article focuses on the topics: Resveratrol & Intracellular.read more
Citations
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Journal ArticleDOI
Selective trapping of live and dead mammalian cells using insulator-based dielectrophoresis within open-top microstructures
Chun-Ping Jen,Teng-Wen Chen +1 more
TL;DR: Insulator-based dielectrophoresis (iDEP) trapping consists of insulating structures which squeeze the electric field in a conductive solution to create a non-uniform electric field, and the iDEP trapping microchip with the open-top microstructures was designed and fabricated.
Journal ArticleDOI
Induction of cytotoxicity and apoptosis in mouse blastocysts by silver nanoparticles
TL;DR: It is shown that in vitro exposure to nanoAg induces apoptosis and retards early post-implantation development after transfer to host mice, and nanoAg-stimulated embryonic cytotoxicity appeared lower than that induced by the Ag+ ion.
Journal ArticleDOI
Therapeutic potential of resveratrol against emerging respiratory viral infections.
TL;DR: An overview of the antiviral activity and potential mechanisms of resveratrol against the respiratory tract viruses considered as a public threat for their rapid transmission and high morbidity and mortality in the general population is presented.
Journal ArticleDOI
Protective effects of resveratrol on ethanol-induced apoptosis in embryonic stem cells and disruption of embryonic development in mouse blastocysts.
TL;DR: It is shown that 0.3-1.0% (w/v) ethanol induces apoptosis in mouse blastocysts and that resveratrol, a grape-derived phytoalexin with known antioxidant and anti-inflammatory properties, prevents ethanol-induced apoptosis and inhibition of cell proliferation.
Journal ArticleDOI
Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.
TL;DR: In this article, the role of caspase-6 activation in 5-fluorouracil (5-FU)-elicited apoptosis as well as the combination effects between RSV and 5-FU on their apoptosis induction was further investigated in the same colon cancer cell model.
References
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Journal ArticleDOI
Apoptosis in the pathogenesis and treatment of disease
TL;DR: In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death, and recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases.
Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Journal Article
Apoptosis, oncosis, and necrosis : an overview of cell death
Guido Majno,Isabelle Joris +1 more
TL;DR: Some of the typical features of apoptosis are discussed, such as budding (as opposed to blebbing and zeiosis) and the inflammatory response, and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage.
Journal ArticleDOI
Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress.
TL;DR: Data suggest that H2O2-Fe(2+)-derived oxidant is mainly responsible for the nonenzymatic oxidation of DCFH, which remains an attractive probe as an overall index of oxidative stress in toxicological phenomena.