Journal ArticleDOI
Dose‐ and time‐related effect of troleandomycin on methylprednisolone elimination
Stanley J. Szefler,Stanley J. Szefler,Manon Brenner,Manon Brenner,William J. Jusko,William J. Jusko,Sheldon L. Spector,Sheldon L. Spector,Kathleen A. Flesher,Kathleen A. Flesher,Elliot F. Ellis,Elliot F. Ellis +11 more
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TLDR
It is suggested that TAO induces immediate and continued inhibition of methylprednisolone disposition and in patients receiving continuous TAO on an every‐other‐day basis, inhibition was impaired to a greater extent on the “day on” TAO than on the“day off’ TAO.Citations
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Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids
TL;DR: Simulations with a pharmacokinetic/pharmacodynamic model using T helper cell counts and endogenous Cortisol as biomarkers for the effects of methylprednisolone suggest that the clinical efficacy of low-dose glucocorticoid regimens might be increased with twice-daily glucocORTicoid administration.
Journal ArticleDOI
Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data
J. A. P. Da Silva,J. W. G. Jacobs,John R. Kirwan,Maarten Boers,Kenneth G. Saag,Luís Inês,E J P de Koning,Frank Buttgereit,Maurizio Cutolo,H Capell,Rolf Rau,Johannes W. J. Bijlsma +11 more
TL;DR: Safety data from recent randomised controlled clinical trials of low dose glucocorticoid treatment in RA suggest that adverse effects associated with this drug are modest, and often not statistically different from those of placebo.
Journal ArticleDOI
Pharmacokinetic Drug Interactions of Macrolides
TL;DR: These incriminated macrolide antibiotics should not be administered concomitantly with other drugs known to be affected metabolically by them, or at the very least, combined administration should be carried out only with careful patient monitoring.
Journal ArticleDOI
Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p
Steven A. Wrighton,Patrick Maurel,Erin G. Schuetz,Paul B. Watkins,Beverly Young,Philip S. Guzelian +5 more
TL;DR: It is concluded that, in addition to glucocorticoids, macrolide antibiotics are specific inducers of P-450p.
Journal ArticleDOI
Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of action.
TL;DR: Macrolide antibiotics administered in sub-antimicrobial doses improve pulmonary function and decrease exacerbation frequency for persons with diffuse panbronchiolitis or cystic fibrosis and possibly reduce mucin production as well as neutrophil migration by interfering with ERK signal transduction.
References
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Journal ArticleDOI
Corticosteroid analysis in biological fluids by high-performance liquid chromatography
James Q. Rose,William J. Jusko +1 more
TL;DR: A sensitive, specific, and reproducible high-performance liquid chromatographic assay for the simultaneous determination of prednisone, prednisolone and cortisol in biological fluids was developed with dexamethasone as the internal standard and a typical plasma concentration--time profile for the three steroids is presented.
Journal ArticleDOI
Troleandomycin: Effectiveness in steroid-dependent asthma and bronchitis☆☆☆
Sheldon L. Spector,Sheldon L. Spector,Fred H. Katz,Fred H. Katz,Richard S. Farr,Richard S. Farr +5 more
TL;DR: The steroid dose-reducing capacity of troleandomycin (Tao), a macrolide antibiotic, was substantiated by a double-blind crossover study of 74 corticosteroid-dependent asthmatic and bronchitic subjects and the antibiotic property of Tao did not explain improvement.
Journal ArticleDOI
The effect of troleandomycin on methylprednisolone elimination
Stanley J. Szefler,James Q. Rose,Elliot F. Ellis,Sheldon L. Spector,Andrew W. Green,William J. Jusko +5 more
TL;DR: TAO inhibition of methylprednisolone clearance may contribute to the beneficial effects observed initially with combined methylpredisonsolone-troleandomycin therapy in severe steroid-dependent asthma.
Journal ArticleDOI
Efficacy of troleandomycin in outpatients with severe, corticosteroid-dependent asthma.
Robert S. Zeiger,Robert S. Zeiger,Michael Schatz,Michael Schatz,William Sperling,William Sperling,Ronald A. Simon,Ronald A. Simon,D.D. Stevenson,D.D. Stevenson +9 more
TL;DR: The present study extends the effectiveness ofTAO therapy to ambulatory asthmatics, establishes a clinical strategy that maximizes benefit/risk factors, and provides practical guidelines for the long-term use of TAO and methylprednisolone.
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