Journal ArticleDOI
Dose escalation of low molecular weight heparin to manage recurrent venous thromboembolic events despite systemic anticoagulation in cancer patients
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TLDR
Cancer patients with recurrent VTE have a short median survival, and Escalating the dose of LMWH can be effective for treating cases that are resistant to standard, weight‐adjusted doses of LM WH or a VKA.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2009-05-01. It has received 194 citations till now. The article focuses on the topics: Low molecular weight heparin.read more
Citations
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Journal ArticleDOI
Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report
Clive Kearon,Elie A. Akl,Elie A. Akl,Joseph Ornelas,Allen J. Blaivas,David Jiménez,Henri Bounameaux,Menno V. Huisman,Christopher S. King,Timothy A. Morris,Namita Sood,Scott M. Stevens,Janine R.E. Vintch,Philip S. Wells,Scott C. Woller,Lisa K. Moores +15 more
TL;DR: Recommendations on 12 topics that were in the 9th edition of these guidelines are updated, and 3 new topics are addressed.
Journal ArticleDOI
2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism
Stavros Konstantinides,Adam Torbicki,David Fitzmaurice,Simón J,R. Gibbs,Menno V. Huisman,Marc Humbert,John Lekakis,Nicolas Meneveau,Lars Hvilsted Rasmussen,Thomas H. Schindler,Anton Vonk Noordegraaf,José Luis Zamorano,Maurizio Zompatori +13 more
TL;DR: Guidelines summarize and evaluate all available evidence at the time of the writing process, on a particular issue with the aim of assisting health professionals in selecting the best management strategies for an individual patient, with a given condition, taking into account the impact on outcome.
Journal ArticleDOI
Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update 2014
Gary H. Lyman,Gary H. Lyman,Kari Bohlke,Alok A. Khorana,Nicole M. Kuderer,Agnes Y.Y. Lee,Juan I. Arcelus,Edward P. Balaban,Jeffrey M. Clarke,Christopher R. Flowers,Charles W. Francis,Leigh E. Gates,Ajay K. Kakkar,Nigel S. Key,Mark Levine,Howard A. Liebman,Margaret A. Tempero,Sandra L. Wong,Mark R. Somerfield,Anna Falanga +19 more
TL;DR: Current recommendations about the prophylaxis and treatment of venous thromboembolism (VTE) in patients with cancer and oncology professionals should educate patients about the signs and symptoms of VTE.
Journal ArticleDOI
Evidence-Based Management of Anticoagulant Therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Anne Holbrook,Sam Schulman,Daniel M. Witt,Per Olav Vandvik,Jason S. Fish,Michael J. Kovacs,Peter Svensson,David L. Veenstra,Mark Crowther,Gordon H. Guyatt +9 more
TL;DR: In this article, the authors focus on the common important management questions for which, at a minimum, low-quality published evidence is available to guide best practices and provide guidance for many common anticoagulation-related management problems.
Journal ArticleDOI
Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update
Nigel S. Key,Alok A. Khorana,Nicole M. Kuderer,Kari Bohlke,Agnes Y. Lee,Juan I. Arcelus,Sandra L. Wong,Edward P. Balaban,Christopher R. Flowers,Charles W. Francis,Leigh E. Gates,Ajay K. Kakkar,Mark Levine,Howard A. Liebman,Margaret A. Tempero,Gary H. Lyman,Anna Falanga +16 more
TL;DR: An Expert Panel convened an Expert Panel to review the evidence and revise previous recommendations as needed to provide updated recommendations about prophylaxis and treatment of venous thromboembolism (VTE) in patients with cancer.
References
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Journal ArticleDOI
Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients: Definitions of major bleeding in clinical studies
S. Schulman,C. Kearon +1 more
TL;DR: A definition of major bleeding in non‐surgical patients was developed that should be applicable to studies with all agents that interfere with hemostasis, including anticoagulants, platelet function inhibitors and fibrinolytic drugs.
Journal ArticleDOI
Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients.
Sam Schulman,U. Angerås,David Bergqvist,Bengt I. Eriksson,Michael R. Lassen,William D. Fisher +5 more
TL;DR: A definition of major bleeding that should be applicable to all agents that interfere with hemostasis is developed and is to seek approval from the regulatory authorities to enhance its incorporation into future clinical trial protocols.
Journal ArticleDOI
Low-Molecular-Weight Heparin versus a Coumarin for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer
Agnes Y.Y. Lee,Mark Levine,Ross I. Baker,Chris Bowden,Ajay K. Kakkar,Martin H. Prins,Frederick R. Rickles,Jim A. Julian,Susan Haley,Michael J. Kovacs,Michael Gent +10 more
TL;DR: In patients with cancer and acute venous thromboembolism, dalteparin was more effective than an oral anticoagulant in reducing the risk of recurrent thrombosis without increasing therisk of bleeding.
Journal ArticleDOI
Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study.
John A. Heit,Marc D. Silverstein,Marc D. Silverstein,David N. Mohr,Tanya M. Petterson,W. Michael O'Fallon,L. Joseph Melton +6 more
TL;DR: Hospital or nursing home confinement, surgery, trauma, malignant neoplasm, chemotherapy, neurologic disease with paresis, central venous catheter or pacemaker, varicose veins, and superficial vein thrombosis are independent and important risk factors for VTE.
Journal ArticleDOI
Antithrombotic therapy for venous thromboembolic disease.
TL;DR: It is shown that patients with symptomatic proximal DVT may benefit from fitted compression stockings for at least 3 months to reduce the incidence of the postthrombotic syndrome, and patients with VTE who receive adequate anticoagulation generally do not die of recurrent disease.
Related Papers (5)
Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update 2014
Gary H. Lyman,Gary H. Lyman,Kari Bohlke,Alok A. Khorana,Nicole M. Kuderer,Agnes Y.Y. Lee,Juan I. Arcelus,Edward P. Balaban,Jeffrey M. Clarke,Christopher R. Flowers,Charles W. Francis,Leigh E. Gates,Ajay K. Kakkar,Nigel S. Key,Mark Levine,Howard A. Liebman,Margaret A. Tempero,Sandra L. Wong,Mark R. Somerfield,Anna Falanga +19 more