Journal ArticleDOI
Doublet frequency analysis of fractionated vertebrate nuclear DNA.
Reads0
Chats0
TLDR
It is concluded that the highly characteristic general design of bulk nDNA, and of the majority of individual sub-fractions of n DNA, is shared by those fractions of nDNA that code for proteins which in turn implies that they have all evolved in response to the same major selection pressures.About:
This article is published in Journal of Molecular Biology.The article was published on 1976-11-25. It has received 157 citations till now. The article focuses on the topics: RNA & Cistron.read more
Citations
More filters
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
DNA methylation and the frequency of CpG in animal DNA.
TL;DR: An analysis of nearest neighbour dinucleotide frequencies and the level of DNA methylation in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate abnormally frequently to T.
Journal ArticleDOI
Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution
Charles M. Rice,Edith M. Lenches,Sean R. Eddy,Se Jung Shin,Rebecca L. Sheets,James H. Strauss +5 more
TL;DR: The sequence of the entire RNA genome of the type flavivirus, yellow fever virus, has been obtained and implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flaviv virus RNA replication and for the evolutionary relation of this virus family to other RNA viruses.
Journal ArticleDOI
5-Methylcytosine in eukaryotic DNA
TL;DR: Methylation of eukaryotic DNA has been proposed to function in many ways, including control of transcription, maintenance of chromosome structure, repair of DNA, establishment of preferred sites for mutation, oncogenic transformation, and, in certain systems, protection of DNA against enzymatic degradation.
Journal ArticleDOI
A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA
TL;DR: Genomic mapping of three nonribosomal fragments showed that they are part of islands of DNA within which nonmethylated Hpa II and Hha I sites are highly concentrated, estimating about 30,000 islands per haploid genome and discussing evidence that many may be associated with genes.
References
More filters
Journal ArticleDOI
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
Repeated Sequences in DNA
Roy J. Britten,D. E. Kohne +1 more
TL;DR: Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms and used in medicine, science, and engineering.
Journal ArticleDOI
Gene Regulation for Higher Cells: A Theory
Roy J. Britten,Eric H. Davidson +1 more
TL;DR: Direct support for the idea that regulation of gene activity underlies cell differentiation comes from evidence that much of the genome in higher cell types is inactive and that different ribonucleic acids are synthesized in different cell types.
Journal ArticleDOI
Determination of the base composition of deoxyribonucleic acid from its buoyant density in CsCl.
TL;DR: A comprehensive study of the buoyant density of DNA as a function of composition has been made and the linear relation previously reported has been confirmed.
Journal ArticleDOI
Non-Darwinian Evolution
Jack Lester King,Thomas H. Jukes +1 more
TL;DR: NonDarwinian evolution of protein and DNA, comparing expectations of evolution models for protein and amino acid changes is compared.