Dual Roles of Granzyme B
TLDR
This review focuses on the positive role of GZMB (in the elimination of tumour cells, bacteria, parasites and viruses, and in the identification, diagnosis and treatment of diseases) and the negative effects of GzMB (with regard to extracellular function and other characteristics).Abstract:
Granzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour cells and bacteria/virus‐infected cells. However, comprehensive studies conducted on GZMB have gradually revealed the negative extracellular functions of GZMB; for example, it is an aetiology and a factor responsible for the aggravation of several diseases. This review focuses on the positive role of GZMB (in the elimination of tumour cells, bacteria, parasites and viruses, and in the identification, diagnosis and treatment of diseases) and the negative effects of GZMB (with regard to extracellular function and other characteristics). The current research on GZMB inhibitors has been briefly introduced, and few studies on GZMB fusion proteins and several GZMB material delivery systems have been discussed.read more
Citations
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Journal ArticleDOI
Granzyme B Mediates Both Direct and Indirect Cleavage of Extracellular Matrix in Skin After Chronic Low-Dose Ultraviolet Light Irradiation
Leigh G. Parkinson,Leigh G. Parkinson,Ana Toro,Ana Toro,Hongyan Zhao,Hongyan Zhao,David J. Granville,David J. Granville +7 more
TL;DR: GzmB deficiency significantly protected against the formation of wrinkles and the loss of dermal collagen density, which was related to the cleavage of decorin, an abundant proteoglycan involved in collagen fibrillogenesis and integrity.
Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzzyme B-mediated apoptosis without perturbing the fast cell death pathway
Phillip I. Bird,Jiuru Sun,Catherina H. Bird,Vivien R. Sutton,Claire E Hirst,Andrea Novak,Sharad Kumar,Joseph A. Trapani +7 more
TL;DR: In this paper, the authors showed that the PI-9 proteinase inhibitor can protect transfected cells against apoptosis induced by either purified granzyme B and perforin or intact CLs.
Journal ArticleDOI
Identification of Spatial Proteomic Signatures of Colon Tumor Metastasis
Listyati Palupi,Carol D. Ryff +1 more
TL;DR: In this article , the authors used the GeoMX Digital Spatial Profiler to identify biomarkers from protein expression patterns inside, at the invasive margin, and away from the tumor, associated with extracellular matrix remodeling, immune suppression, forkhead box P3, exhaustion and cytotoxicity, CD8, Programmed death ligand 1-expressing dendritic cells, and neutrophil proliferation.
Posted ContentDOI
Identification of Spatial Proteomic Signatures of Colon Tumor Metastasis: A Digital Spatial Profiling Approach
Joshua J. Levy,John Zavras,Eren M Veziroglu,Mustafa Nasir-Moin,Fred W. Kolling,Brock C. Christensen,Lucas A. Salas,Rachael E. Barney,Scott M. Palisoul,Bing Ren,Xiaoying Liu,Darcy A. Kerr,Kelli B. Pointer,Gregory J. Tsongalis,Louis J. Vaickus +14 more
TL;DR: In this article , the authors used the GeoMX Digital Spatial Profiler (DSP) to identify biomarkers from DSP-assayed protein expression patterns inside, at the invasive margin, and away from the tumor, associated with extracellular matrix remodeling.
Journal ArticleDOI
Intraepithelial cytotoxic lymphocytes are associated with a poor prognosis in feline intestinal T-cell lymphoma
Tatshuhito Ii,James K. Chambers,Ko Nakashima,Yuko Goto-Koshino,Takuya Mizuno,Kazuyuki Uchida +5 more
TL;DR: In this paper , the expression of cytotoxic molecules in feline intestinal T-cell lymphoma cells was examined immunohistochemically using endoscopic samples of 50 cases.
References
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Journal ArticleDOI
The immune contexture in human tumours: impact on clinical outcome
Wolf H. Fridman,Franck Pagès,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Jérôme Galon +5 more
TL;DR: In this Opinion article, the context-specific nature of infiltrating immune cells can affect the prognosis of patients is discussed.
Journal ArticleDOI
Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility
Keith G. Danielson,Helene Baribault,David F. Holmes,Helen K. Graham,Karl E. Kadler,Renato V. Iozzo +5 more
TL;DR: A fundamental role is demonstrated for decorin in regulating collagen fiber formation in vivo in mice harboring a targeted disruption of the decorin gene, which provides an explanation for the reduced tensile strength of the skin.
Journal ArticleDOI
Cytotoxic T lymphocytes: all roads lead to death
Michele Barry,R. Chris Bleackley +1 more
TL;DR: An understanding of the mechanisms that are used by CTLs to destroy targets and a knowledge of pathogen immune-evasion strategies will provide vital information for the design of new therapies.
Journal ArticleDOI
Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors GENERATION OF RECEPTOR-SELECTIVE VEGF VARIANTS BY SITE-DIRECTED MUTAGENESIS
Bruce Keyt,Hung Nguyen,Lea T. Berleau,Carlos M. Duarte,Jeanie Park,Helen Chen,Napoleone Ferrara +6 more
TL;DR: Results suggest dual sets of determinants in the VEGF dimer that cross-link cell surface receptors, triggering endothelial cell growth and angiogenesis and implicates KDR, but not FLT-1, in V EGF induction of endothelialcell proliferation.
Journal ArticleDOI
Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine
TL;DR: This review of CD44 receptor biology and its involvement in the different stages of tumor growth and metastasis, as well as methods currently used for targeting the receptor, outlines a number of research approaches from the current literature that take advantage of hyaluronic acid’s targeting ability.