Journal ArticleDOI
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin
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TLDR
The data suggested that baicalin could attenuate HTG-AP, possibly through regulating B7H4/JAK2/STAT3 signaling.About:
This article is published in Digestive Diseases and Sciences.The article was published on 2022-07-04. It has received 2 citations till now. The article focuses on the topics: Medicine & Baicalin.read more
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Journal ArticleDOI
Natural Chinese herbs for the prevention and treatment of acute pancreatitis: a narrative review
Peer ReviewDOI
Natural Chinese herbs for the prevention and treatment of acute pancreatitis: a narrative review
TL;DR: Wang et al. as discussed by the authors summarized the pathophysiological mechanisms underlying pancreatitis and reviewed the potential role of natural Chinese herbs (monomers and decoctions) in clinical and basic research.
References
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Journal ArticleDOI
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
Gabriel Sica,In Hak Choi,In Hak Choi,Gefeng Zhu,Koji Tamada,Shengdian Wang,Hideto Tamura,Andrei I. Chapoval,Dallas B. Flies,Jürgen Bajorath,Jürgen Bajorath,Lieping Chen +11 more
TL;DR: A B7 family molecule, B7-H4, is identified by protein sequence analysis and comparative molecular modeling and may participate in negative regulation of cell-mediated immunity in peripheral tissues.
Journal ArticleDOI
American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis.
Seth D. Crockett,Sachin Wani,Timothy B. Gardner,Yngve Falck-Ytter,Yngve Falck-Ytter,Alan N. Barkun,Seth Crockett,Joseph D. Feuerstein,Steven L. Flamm,Ziad F. Gellad,Lauren B. Gerson,Samir Gupta,Ikuo Hirano,John M. Inadomi,Geoffrey C. Nguyen,Joel H. Rubenstein,Siddharth Singh,Walter E. Smalley,Neil Stollman,Sarah Street,Shahnaz Sultan,Santhi Swaroop Vege,Sachin Wani,David H. Weinberg +23 more
TL;DR: The American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis provides a guide for the initial management of acute pancreatic cancer patients.
Journal ArticleDOI
B7S1, a Novel B7 Family Member that Negatively Regulates T Cell Activation
TL;DR: A novel addition in the B7 family is described, designated as B7S1, which is uniquely anchored to the cell membrane via a GPI linkage, which identifies a novel negative regulator of T cell activation and further reveals complex costimulatory regulation of immune responses.
Journal ArticleDOI
Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies
Amy Y. Xiao,Marianne L Y Tan,Landy M. Wu,Varsha M. Asrani,John A. Windsor,Dhiraj Yadav,Maxim S. Petrov +6 more
TL;DR: Global estimates of the incidence and mortality of major pancreatic diseases in high-quality population-based cohort studies showed that acute pancreatitis is the most common pancreatic disease whilst pancreatic cancer is themost lethal, however, their burden is not equal across the globe.
Journal ArticleDOI
Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis.
Haq Nawaz,Efstratios Koutroumpakis,Jeffrey J. Easler,Adam Slivka,David C. Whitcomb,Vijay P. Singh,Dhiraj Yadav,Georgios I. Papachristou +7 more
TL;DR: Elevated serum TGs in AP patients are independently and proportionally correlated with persistent organ failure regardless of etiology, and TG-mediated lipotoxicity may be an attractive target to design novel interventions for severe AP.