Effect of brain shift on the creation of functional atlases for deep brain stimulation surgery

TLDR: The results indicate that considerable brain shift happens before micro-electrode recordings in DBS but also that brain shift affects the creation of accurate functional atlases, and care must be taken when building and using such atlase of intra-operative data and also when using intra-operatively data to validate anatomical atlased.

Abstract: Purpose In the recent past many groups have tried to build functional atlases of the deep brain using intra-operatively acquired information such as stimulation responses or micro-electrode recordings An underlying assumption in building such atlases is that anatomical structures do not move between pre-operative imaging and intra-operative recording In this study, we present evidences that this assumption is not valid We quantify the effect of brain shift between pre-operative imaging and intra-operative recording on the creation of functional atlases using intra-operative somatotopy recordings and stimulation response data