Journal ArticleDOI
Effect of lupeol, a pentacyclic triterpene, on the lipid peroxidation and antioxidant status in rat kidney after chronic cadmium exposure.
TLDR
Lupeol, when supplemented at a dosage of 40 mg kg−1 body weight concurrent with cadmium administration, showed an improvement in the antioxidant status and the level of lipid peroxides showed a significant decrease, which shows the nephroprotective action of the drug.Abstract:
This study pertains to the role of lupeol, a pentacyclic triterpene, against the toxic manifestations of chronic cadmium exposure. Cadmium is a potent nephrotoxin on prolonged exposure. Cadmium (as cadmium chloride) at a dose of 1 mg kg−1 body weight was administered subcutaneously for 15 days to rats. This led to an increase in the level of lipid peroxides and a decrease in the level of antioxidants in the kidney. Lupeol, when supplemented at a dosage of 40 mg kg−1 body weight concurrent with cadmium administration, showed an improvement in the antioxidant status. The level of lipid peroxides also showed a significant decrease, which shows the nephroprotective action of the drug Copyright © 2000 John Wiley & Sons, Ltd.read more
Citations
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Toxicological Profile for Cadmium
Obaid Faroon,Annette Ashizawa,Scott Wright,Pam Tucker,Kim Jenkins,Lisa Ingerman,Catherine Rudisill +6 more
TL;DR: This public health statement tells you about cadmium and the effects of exposure to it and the possibility exists that the number of sites at which Cadmium is found may increase in the future as more sites are evaluated.
Journal ArticleDOI
Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy.
TL;DR: This review summarizes the potential of triterpenes belonging to the lupane, oleanane or ursane group, to treat cancer by different modes of action and utilisation of different plants as their sources is of interest.
Journal ArticleDOI
Beneficial health effects of lupeol triterpene: A review of preclinical studies
TL;DR: Lupeol has been found to be pharmacologically effective in treating various diseases under preclinical settings (in animal models) irrespective of varying routes of administration viz; topical, oral, intra-peritoneal and intravenous as mentioned in this paper.
Journal ArticleDOI
Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice
TL;DR: It is suggested that Lupeol is an attractive antitumor-promoting agent that must be evaluated in tumor models other than skin carcinogenesis, and inhibits conventional as well as novel biomarkers of tumor promotion.
Journal ArticleDOI
Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium
TL;DR: In this article, the effect of vitamins C and E supplementation on Cd-treated mice testes was evaluated and the role of vitamins in reducing oxidative stress-related effects on spermatogenesis was reported.
References
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Protein Measurement with the Folin Phenol Reagent
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Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
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Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
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Journal ArticleDOI
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
Jozef Sedlak,Raymond H. Lindsay +1 more
TL;DR: A simple spectrophotometric method for the routine concomitant determination of sulfhydryl groups in PB- SH, NP-SH, and T-SH fractions in various tissues is reported.
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Selenium: Biochemical Role as a Component of Glutathione Peroxidase
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