Journal ArticleDOI
Effect of weight loss on bone metabolism: comparison of vertical banded gastroplasty and medical intervention.
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The data indicate that weight loss causes bone loss, independent of the method of weight reduction, and measuring BMD appears to be the only reliable method for screening.Abstract:
Background: We studied the effects of weight loss on bone metabolism. Methods: 16 consecutive surgically-treated (14 female, 2 male) morbidly obese patients and 65 obese (53 male, 12 female) medically-treated patients were enrolled in an observational study. Surgical treatment for morbidly obese patients was vertical banded gastroplasty (VBG). Studies were performed prior to and 12 months after the start of treatment. Bone mineral density (BMD), bone turnover markers, sex steroids, calcium excretion and parathyroid hormone measurements were done at each visit. Results: Weight loss was more prominent with surgical than with medical treatments. Bone loss was also pronounced in the surgical treatment group, and occurred at the hip level only (P<0.05). Compared to previously reported studies, where the effects of malabsorptive treatments for obesity on bone metabolism were studied, calcium excretion and parathyroid hormone levels did not change after VBG or medical therapy. For both groups, bone markers indicated an increased bone turnover, evidenced by increased urinary excretion of deoxypyridinoline and serum levels of osteocalcin (P<0.05). Sex steroid measurements revealed a decrease in estradiol levels in the surgical treatment group, but not in medical treatment group. This finding was thought to be secondary to less weight loss in the medical group. Conclusion: Our data indicate that weight loss causes bone loss. The bone loss is independent of the method of weight reduction. However, the mechanism of the bone loss is not clear. It may be explained partly by reduced estradiol levels in female patients. Because the mechanisms of bone disease after weight loss remain unclear, it is difficult to determine the most effective treatment. It is important to detect osteopenia early, before fractures occur. Measuring BMD appears to be the only reliable method for screening.read more
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Journal ArticleDOI
Relationship of obesity with osteoporosis.
Lan Juan Zhao,Yong Jun Liu,Pengyuan Liu,James A. Hamilton,Robert R. Recker,Hong-Wen Deng,Hong-Wen Deng,Hong-Wen Deng +7 more
TL;DR: The relationship between obesity and osteoporosis is reevaluate by accounting for the mechanical loading effects of total body weight on bone mass and the phenotypic correlation between fat mass and fat mass was negative, suggesting increasing fat mass may not have a beneficial effect on bonemass.
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ASMBS Allied Health Nutritional Guidelines for the Surgical Weight Loss Patient
TL;DR: Allied Health Sciences Section Ad Hoc Nutrition Committee: Linda Aills, R.S., R.D., Cynthia Buffington, Ph.D, and Jeanne Blankenship, M.S.
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Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass.
Penelope S. Coates,John D. Fernstrom,Madelyn H. Fernstrom,Philip R. Schauer,Susan L. Greenspan +4 more
TL;DR: Within 3 to 9 months after LRGB, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass, and additional studies are needed to examine these findings over the longer term.
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Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: a randomized clinical trial.
Torsten Olbers,Sofia Björkman,Ak Lindroos,Almantas Maleckas,Lars Lönn,Lars Sjöström,Hans Lönroth +6 more
TL;DR: A “steering” away from fatty foods after LGBP may be an important mechanism of action in gastric bypass, and energy expenditure developed as expected postoperatively.
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Nutrient deficiencies secondary to bariatric surgery.
TL;DR: This review describes the literature published in the last few years concerning nutritional deficiencies after bariatric surgery as well as their etiology, incidence, treatment and prevention and gives special attention to adolescents, mainly girls at reproductive age who have a substantial risk of developing iron deficiency.
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Relation between Body Size and Bone Mineral Density in Elderly Men and Women
TL;DR: In this cohort, all measures of body size were associated with bone mineral density in both sexes and were better markers of bone mineraldensity in the weight-bearing sites than in the non-weight- bearing sites, implying a mechanical effect of weight on bone Mineral density.
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TL;DR: Overweight postmenopausal women benefit from addition of combined aerobic and anaerobic exercise to an energy-restrictive diet, and the diet itself has a positive effect on cardiovascular risk factors.
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Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation
TL;DR: Its production before the increase in transcription of matrix protein mRNA, and before the transcription of IGF-I mRNA in bone surface cells, represents persuasive evidence for a role for osteocytes, and for IGF- I, in the osteogenic response of bone to mechanical stimulation.