Journal ArticleDOI
Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction.
Shao-liang Chen,Wu-wang Fang,Fei Ye,Yu-Hao Liu,Jun Qian,Shou-jie Shan,Jun-jie Zhang,Robert Zhao Chunhua,Lian-ming Liao,Song Lin,Jing-ping Sun +10 more
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TLDR
Several imagining techniques demonstrated that bone marrow mesenchymal stem cells significantly improved left ventricular function in patients undergoing primary percutaneous coronary intervention.Abstract:
Sixty-nine patients who underwent primary percutaneous coronary intervention within 12 hours after onset of acute myocardial infarction were randomized to receive intracoronary injection of autologous bone marrow mesenchymal stem cell or standard saline. Several imagining techniques demonstrated that bone marrow mesenchymal stem cells significantly improved left ventricular function.read more
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Journal ArticleDOI
Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood.
Wolfgang Wagner,Frederik Wein,Anja Seckinger,Maria Frankhauser,Ute Wirkner,Ulf Krause,Jonathon Blake,Christian Schwager,Volker Eckstein,Wilhelm Ansorge,Anthony D. Ho +10 more
TL;DR: The results have provided a foundation for a more reproducible and reliable quality control using genotypic analysis for defining MSC.
Journal ArticleDOI
Regenerating the heart.
TL;DR: Future research is likely to focus on improving the ability to guide the differentiation of stem cells, control their survival and proliferation, identify factors that mediate their homing and modulate the heart's innate inflammatory and fibrotic responses.
Journal ArticleDOI
Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis.
Ahmed Abdel-Latif,Roberto Bolli,Imad M. Tleyjeh,Victor M. Montori,Emerson C. Perin,Carlton A. Hornung,Ewa K. Zuba-Surma,Mouaz H. Al-Mallah,Buddhadeb Dawn +8 more
TL;DR: The available evidence suggests that BMC transplantation is associated with modest improvements in physiologic and anatomic parameters in patients with both acute myocardial infarction and chronic ischemic heart disease, above and beyond conventional therapy.
Journal ArticleDOI
Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis.
Dimitrios Karussis,Clementine Karageorgiou,Adi Vaknin-Dembinsky,Basan Gowda-Kurkalli,John M. Gomori,Ibrahim Kassis,Jeff W.M. Bulte,Panayiota Petrou,Tamir Ben-Hur,Oded Abramsky,Shimon Slavin +10 more
TL;DR: Transplantation of MSCs in patients with MS and ALS is a clinically feasible and relatively safe procedure and induces immediate immunomodulatory effects.
Journal ArticleDOI
Mesenchymal Stromal Cells: Current Understanding and Clinical Status†
TL;DR: This review highlights the current understanding into the biology of MSCs with particular emphasis on the cardiovascular and renal applications, and provides a brief update on the clinical status of M SC‐based therapy.
References
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Journal ArticleDOI
Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.
Marc A. Pfeffer,Eugene Braunwald +1 more
TL;DR: The extent of ventricular enlargement after infarction is related to the magnitude of the initial damage to the myocardium and, although an increase in cavity size tends to restore stroke volume despite a persistently depressed ejection fraction, ventricular dilation has been associated with a reduction in survival.
Journal ArticleDOI
In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
TL;DR: A culture system that facilitates the chondrogenic differentiation of rabbit bone marrow-derived mesenchymal progenitor cells has been developed in this article, where cells obtained in bone marrow aspirates were first isolated by monolayer culture and then transferred into tubes and allowed to form three-dimensional aggregates in a chemically defined medium.
Journal ArticleDOI
Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans
Bodo E. Strauer,Michael A. Brehm,Tobias Zeus,Matthias Köstering,Anna Hernandez,Rüdiger V. Sorg,Gesine Kögler,Peter Wernet +7 more
TL;DR: Ten patients who were treated by intracoronary transplantation of autologous, mononuclear bone marrow cells (BMCs) in addition to standard therapy after MI found that the infarct region had decreased significantly within the cell therapy group and was also significantly smaller compared with the standard therapy group.
Journal ArticleDOI
Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5‐azacytidine
TL;DR: Support is provided for the suggestion that mesenchymal stem cells in the bone marrow of postnatal organisms may provide a source for myoprogenitor cells which could function in clinically relevant myogenic regeneration.
Journal ArticleDOI
The Evolving Concept of a Stem Cell: Entity or Function?
TL;DR: This work was supported by a Lutheran Fellowship and an NIH predoctoral training grant GM07149 to T.B.R. and by NIH grants CA59717, AG09521, HD 18179, and HL65572 to H.M. Reid.