Journal ArticleDOI
Effects of estrogen replacement therapy on peripheral vasomotor function in postmenopausal women
TLDR
Although acute intraarterial infusion of 17 beta-estradiol potentiates endothelium-dependent vasodilation in the forearms of postmenopausal women, this effect is not maintained with a 3-week cycle of systemic estradiol administration.Abstract:
Hormone replacement therapy is associated with a reduction in cardiovascular events in postmenopausal women. We have recently found that acute 17β-estradiol administration improves endothelium-dependent vasodilation in both the peripheral and coronary circulations of postmenopausal women. The current study was undertaken in 33 estrogen-deficient postmenopausal women (meanage 59 ± 7 years) to determine if short-term estrogen replacement therapy also improves endothelium-dependent vasodilation in peripheral circulation. Acute intraarterial infusion of estradiol, which increased forearm venous estradiol levels from 16 ± 11 to 345 ± 202 pg/ml, potentiated forearm vasodilation induced by the endothelium-dependent vasodilator acetylcholine by 49 ± 67% (pread more
Citations
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Journal ArticleDOI
Potential health benefits of dietary phytoestrogens : A review of the clinical, epidemiological, and mechanistic evidence
TL;DR: Accumulating evidence from molecular and cellular biology experiments, animal studies, and, to a limited extent, human clinical trials suggests that phytoestrogens may potentially confer health benefits related to cardiovascular diseases, cancer, osteoporosis, and menopausal symptoms.
Journal ArticleDOI
Aging and vascular endothelial function in humans
TL;DR: Several lifestyle and biological factors modulate vascular endothelial function with aging, including regular aerobic exercise, dietary factors, vitamin D status, menopause/oestrogen deficiency and a number of conventional and non-conventional risk factors for CVD.
Journal ArticleDOI
Endothelial function in health and disease: new insights into the genesis of cardiovascular disease
TL;DR: The role of NO in human health and disease is described and strategies currently being used to measure and improve endothelial dysfunction are summarized.
Journal ArticleDOI
Serial Assessment of the Cardiovascular System in Normal Pregnancy Role of Arterial Compliance and Pulsatile Arterial Load
Athena Poppas,Sanjeev G. Shroff,Claudia E. Korcarz,Judith U. Hibbard,D.S. Berger,Marshall D. Lindheimer,Roberto M. Lang +6 more
TL;DR: The pulsatile arterial load alterations during normal pregnancy are adaptive in that they help to accommodate the increased intravascular volume while maintaining the efficiency of ventricular-arterial coupling and diastolic perfusion pressure.
Journal ArticleDOI
Hormonal therapy increases arterial compliance in postmenopausal women
Chakravarthi Rajkumar,Bronwyn A. Kingwell,James D. Cameron,Tamara K. Waddell,Rishi Mehra,Nicholas Christophidis,Paul A. Komesaroff,B. P. McGrath,Garry L. Jennings,Krishnankutty Sudhir,Anthony M. Dart +10 more
TL;DR: The increased SAC and decreased PWV in women receiving hormonal therapy suggest that such therapy may decrease stiffness of the aorta and large arteries in postmenopausal women, with potential benefit for age-related cardiovascular disorders.
References
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Journal ArticleDOI
Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study.
Meir J. Stampfer,Graham A. Colditz,Walter C. Willett,JoAnn E. Manson,Bernard Rosner,Frank E. Speizer,Charles H. Hennekens +6 more
TL;DR: Current estrogen use is associated with a reduction in the incidence of coronary heart disease as well as in mortality from cardiovascular disease, but it is not associated with any change in the risk of stroke.
Journal ArticleDOI
Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence☆☆☆
TL;DR: The bulk of the evidence strongly supports a protective effect of estrogens that is unlikely to be explained by confounding factors and is consistent with the effect of Estrogen on lipoprotein subfractions.
Book
Primer of Applied Regression & Analysis of Variance
TL;DR: In this paper, the authors discuss the multivariate analysis of linear regression regression with two or more independent variables and propose a solution to the problem of multicollinearity.
Journal ArticleDOI
Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins.
Brian W. Walsh,Isaac Schiff,Bernard Rosner,Louise Greenberg,Veronica A. Ravnikar,Frank M. Sacks +5 more
TL;DR: Two randomized, double-blind crossover studies in healthy postmenopausal women who had normal lipid values at base line found that estrogen-replacement therapy may reduce the risk of cardiovascular disease and this beneficial effect may be mediated in part by favorable changes in plasma lipid levels.
Journal ArticleDOI
Estrogen and coronary heart disease in women.
TL;DR: The evidence that estrogen is protective against the development of cardiovascular disease in women is reviewed and the protection is biologically plausible and the magnitude of the benefit would be quite large if selection factors can be excluded.
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