Journal ArticleDOI
Effects of histrionicotoxin on the chemosensitive and electrical properties of skeletal muscle.
A.J. Lapa,A.J. Lapa,E.X. Albuquerque,E.X. Albuquerque,J.M. Sarvey,J.M. Sarvey,John W. Daly,John W. Daly,Bernhard Witkop,Bernhard Witkop +9 more
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It is suggested that HTX acts on the ionic conductance modulator of the acetylcholine receptor in a manner similar to its semisynthetic derivative perhydrohistrionicotoxin, which has a variety of effects on the function of mammalian and amphibian nerve-muscle preparations.About:
This article is published in Experimental Neurology.The article was published on 1975-06-01. It has received 54 citations till now. The article focuses on the topics: Acetylcholine & Neuromuscular junction.read more
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Classification of skin alkaloids from neotropical poison-dart frogs (Dendrobatidae).
TL;DR: A wide range of biological activity of the dendrobatid alkaloids is indicated by injection of unresolved alkaloid fractions into white mice: extracts from different species of Dendrobates produce reactions as diverse as Straub tail, penile erection, prostration, convulsions and salivation.
Journal ArticleDOI
A Formal [3 + 3] Cycloaddition Approach to Natural-Product Synthesis
TL;DR: In this paper, a formal [3 + 3] cycloaddition strategy for constructing complex heterocycles is reviewed, which involves condensation of α,β-unsaturated iminium salts with 1,3-dicarbonyl equivalents.
Journal ArticleDOI
Synthetic approaches towards alkaloids bearing α-tertiary amines
TL;DR: Some approaches to asymmetrically access ATAs are reviewed and an overview of alkaloid total syntheses where those have been employed is provided and it is provided that fewer methods than previously described are commonly used in synthesis.
Book ChapterDOI
Chapter One - Alkaloids from Amphibian Skins
Journal ArticleDOI
Biochemical properties of the brain phencyclidine receptor
Jacques Vignon,Jean-Pierre Vincent,Jean-Noël Bidard,J.-M. Kamenka,Patrick Geneste,Solange Monier,Michel Lazdunski +6 more
TL;DR: This paper gives a detailed account of techniques which can be used to measure [3H]phencyclidine binding to its receptor and the main properties of the binding component, which is rapidly heat-inactivated at temperatures over 50 degrees C and destroyed by proteases suggesting that it is of a protein nature.
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Journal ArticleDOI
Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: The identity of the ions which carry the various phases of the membrane current is chiefly concerned with sodium ions, since there is much evidence that the rising phase of the action potential is caused by the entry of these ions.
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The Selective Inhibition of Delayed Potassium Currents in Nerve by Tetraethylammonium Ion
TL;DR: The pharmacological data demonstrate that the Na, K, and leakage permeabilities are chemically independent, probably because their mechanisms occupy different sites on the nodal membrane.
Journal ArticleDOI
Ionic movements and electrical activity in giant nerve fibres.
TL;DR: In a subsequent article, Young as mentioned in this paper pointed out that the tubular structures must have seemed too large to be nerve fibres, and he first took them to be blood vessels, but on examining them more closely, he was able to prove that the tubes were, in fact, nerve fibers of exceptional size.
Journal ArticleDOI
Anomalous rectification in the squid giant axon injected with tetraethylammonium chloride.
TL;DR: Experiments on fibers in an external medium of high potassium ion concentration demonstrate that injected tetraethylammonium chloride causes rectification of the instantaneous current-voltage curve for potassium by excluding outward current.