Effects of low dose acrylamide on the rat reproductive organs structure, fertility and gene integrity
Saleh Al-Karim,Sufyan ElAssouli,Soad Shaker Ali,Nasra Naeim Ayuob,Nasra Naeim Ayuob,Zaki ElAssouli +5 more
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TLDR
Acrylamide cause harmful effect on the reproductive organ structure, fertility and cause extensive DNA damage in peripheral blood lymphocytes.About:
This article is published in Asian Pacific Journal of Reproduction.The article was published on 2015-09-01 and is currently open access. It has received 27 citations till now. The article focuses on the topics: Acrylamide.read more
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Acrylamide: A review about its toxic effects in the light of Developmental Origin of Health and Disease (DOHaD) concept
TL;DR: This review aimed to present some aspects regarding the acrylamide formation, its toxicokinetics, the occurrence of acrieslamide in foods, the recent findings about its effects on different systems and the consequences for the human healthy.
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Therapeutic potential of quercetin against acrylamide induced toxicity in rats.
TL;DR: Results revealed that QE is able to significantly alleviate the toxicity induced by AA in rats, which was confirmed by decreased acetylcholinesterase (AChE) activity.
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In Vivo acrylamide exposure may cause severe toxicity to mouse oocytes through its metabolite glycidamide.
TL;DR: Oocytes, reaching the M-II stage in the in vivo ACR-treated group, were characterized by a decrease in meiotic spindle mass and an increase in chromosomal disruption, indicating that ACR toxicity on female germ cells may occur through its metabolite, GLY.
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Acrylamide impairs ovarian function by promoting apoptosis and affecting reproductive hormone release, steroidogenesis and autophagy-related genes: An in vivo study.
Nouf Aldawood,Abdulkarem Alrezaki,Shamsa Alanazi,Nabil Amor,Saleh Alwasel,Alexander V. Sirotkin,Abdel Halim Harrath +6 more
TL;DR: It is found that ACR acts by significantly reducing ovarian weight and serum progesterone and estradiol concentrations, and leading to pyknotic, heterochromatic characteristics and nuclear fragmentation, as evidenced by hematoxylin staining.
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Is Acrylamide as Harmful as We Think? A New Look at the Impact of Acrylamide on the Viability of Beneficial Intestinal Bacteria of the Genus Lactobacillus
TL;DR: It is concluded that acrylamide present in food could modulate the viability of LAB and, therefore, could influence their activity in food products or, after colonization, in the human intestine.
References
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Analysis of Acrylamide, a Carcinogen Formed in Heated Foodstuffs
TL;DR: Consumption habits indicate that the acrylamide levels in the studied heated foods could lead to a daily intake of a few tens of micrograms, and the various analytic data should be considered as proof of the identity of acylamide.
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The Ames Salmonella/microsome mutagenicity assay
Kristien Mortelmans,Errol Zeiger +1 more
TL;DR: Historical aspects of how the Ames test was developed and detailed procedures for performing the test, including the design and interpretation of results are provided, to determine the mutagenic potential of new chemicals and drugs.
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Chemistry, biochemistry, and safety of acrylamide. A review.
TL;DR: The potential of exposure to acrylamide has been extensively studied in cells, tissues, animals, and humans as mentioned in this paper, and the effects of exposure in humans have been extensively investigated.
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Acrylamide: its metabolism, developmental and reproductive effects, genotoxicity, and carcinogenicity.
TL;DR: The data show that acrylamide is capable of inducing genotoxic, carcinogenic, developmental, and reproductive effects in tested organisms and may pose more than a neurotoxic health hazard to exposed humans.
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The carcinogenicity of acrylamide.
TL;DR: In this article, a significant fraction of ingested acrylamide is converted metabolically to the chemically reactive and genotoxic epoxide, glycidamide, which is likely to play an important role in the carcinogenicity of acrylimide.
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