Effects of Panicum miliaceum L. extract on adipogenic transcription factors and fatty acid accumulation in 3T3-L1 adipocytes
Mi-Young Park,Dong-Won Seo,Jin Young Lee,Mi-Kyung Sung,Young Min Lee,Hwan-Hee Jang,Hae-Yeon Choi,Jae-Hyn Kim,Dong-Sik Park +8 more
TLDR
The results suggest that some cereals efficiently suppress adipogenesis in 3T3-L1 adipocytes, and the effect of P. miliaceum L. on adipocyte differentiation is associated with the downregulation of adipogenic genes and fatty acid accumulation in adipocytes.Abstract:
The dietary intake of whole grains is known to reduce the incidence of chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. To investigate whether there are anti-adipogenic activities in various Korean cereals, we assessed water extracts of nine cereals. The results showed that treatment of 3T3-L1 adipocytes with Sorghum bicolor L. Moench, Setaria italica Beauvois, or Panicum miliaceum L. extract significantly inhibited adipocyte differentiation, as determined by measuring oil red-O staining, triglyceride accumulation, and glycerol 3-phosphate dehydrogenase activity. Among the nine cereals, P. miliaceum L. showed the highest anti-adipogenic activity. The effects of P. miliaceum L. on mRNA expression of peroxisome proliferator-activated receptor-γ, sterol regulatory element-binding protein 1, and the CCAAT/enhancer binding protein-α were evaluated, revealing that the extract significantly decreased the expression of these genes in a dose-dependent manner. Moreover, P. miliaceum L. extract changed the ratio of monounsaturated fatty acids to saturated fatty acids in adipocytes, which is related to biological activity and cell characteristics. These results suggest that some cereals efficiently suppress adipogenesis in 3T3-L1 adipocytes. In particular, the effect of P. miliaceum L. on adipocyte differentiation is associated with the downregulation of adipogenic genes and fatty acid accumulation in adipocytes.read more
Citations
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Effect of Gambisan on the Inhibition of Adipogenesis in 3T3-L1 Adipocytes
TL;DR: Gambisan significantly inhibited adipogenesis in 3T3-L1 cells by reducing triglyceride contents and lipid accumulation in a dose-dependent manner without obvious cytotoxicity and could act as a possible therapeutic agent for obesity.
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Germinated Brown Rice Extract Inhibits Adipogenesis Through the Down-regulation of Adipogenic Genes in 3T3-L1 Adipocytes
TL;DR: Data suggest that GBR exhibits an anti-adipogenic effect through the suppression of adipogenesis in 3T3-L1 adipocytes, and tumor necrosis factor-α and interlukin-6 mRNA expressions were attenuated by GBR in mature adipocytes.
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Epimedium koreanum Nakai and its main constituent icariin suppress lipid accumulation during adipocyte differentiation of 3T3-L1 preadipocytes
TL;DR: It is indicated that HE extract and icariin can inhibit the adipocyte differentiation through downregulation of the adipogenic transcription factors, suggesting that HE containing icARIin may be used as a potential therapeutic agent in the treatment and prevention of obesity.
Journal ArticleDOI
Anti-aging Potential of Extracts Prepared from Fruits and Medicinal Herbs Cultivated in the Gyeongnam Area of Korea
Myung-Soo Shon,Yunjeong Lee,Ji-Hye Song,Taehyun Park,Jun Kyoung Lee,Minju Kim,Eunju Park,Gyo-Nam Kim +7 more
TL;DR: Fruits and medicinal herbs native to the Gyeongnam area of Korea have strong effects on cell-based systems, including H2O2-induced oxidative stress in human keratinocytes and 3T3-L1 lipid accumulation and may be natural anti-aging materials with effective antioxidant and anti-adipogenic activities.
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Hog millet (Panicum miliaceum L.)-supplemented diet ameliorates hyperlipidemia and hepatic lipid accumulation in C57BL/6J-ob/ob mice
Mi-Young Park,Hwan-Hee Jang,Jung Bong Kim,Hyun Nye Yoon,Jin-Young Lee,Youngmin Lee,Jae-Hyun Kim,Dong-Sik Park +7 more
TL;DR: The results suggest that PME is useful in the chemoprevention or treatment of obesity and obesity-related disorders.
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