Journal ArticleDOI
Effects of physicochemical properties and other factors on systemic nasal drug delivery.
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This article is published in Advanced Drug Delivery Reviews.The article was published on 1998-01-05. It has received 297 citations till now. The article focuses on the topics: Drug delivery.read more
Citations
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Journal ArticleDOI
Cyclodextrins in drug delivery
TL;DR: In the pharmaceutical industry cyclodextrins have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs, and to increase their bioavailability and stability.
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Intranasal delivery: physicochemical and therapeutic aspects.
TL;DR: The present review provides an in-depth discussion of therapeutic aspects of IN delivery including consideration of the intended indication, regimen, and patient population, as well as physicochemical properties of the drug itself.
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Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives.
TL;DR: New classes of functionalized mucoadhesive polymers, the characterization and safety aspects of nasal drug products as well as the opportunities presented by nasal drug delivery are extensively discussed.
Journal ArticleDOI
Intranasal Drug Delivery: How, Why and What for?
TL;DR: The relevant aspects of nasal anatomy, physiology and histology, and the biological, physicochemical and pharmaceutical factors that must be considered during the process of discovery and development of nasal drugs as well as in their incorporation into appropriate nasal pharmaceutical formulations are outlined.
Journal ArticleDOI
Cyclodextrins: structure, physicochemical properties and pharmaceutical applications
TL;DR: How too much or too little CD can hamper drug bioavailability, and the role of CDs in solid dosage forms and parenteral formulations, is explained, and examples given on how CDs can enhance drug delivery after ocular, nasal and pulmonary administration.
References
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Journal ArticleDOI
Chitosan as a Novel Nasal Delivery System for Peptide Drugs
TL;DR: A nasal solution formulation of the cationic material chitosan was shown to greatly enhance the absorption of insulin across the nasal mucosa of rat and sheep.
Journal Article
On the mechanism of intestinal absorption of drugs
TL;DR: The intestinal absorption of acidic drugs is decreased and the absorption of basic drugs increased severalfold when the pH of the intestinal contents is raised from 4 to 8 and this supports the hypothesis that the intestinal mucosa preferentially allows theabsorment of the unionized form of a drug.
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Analysis of Structural Requirements for the Absorption of Drugs and Macromolecules from the Nasal Cavity
TL;DR: It is argued that the most likely route for transport is through junctions between cells and that surface-active adjuvants which markedly enhance insulin uptake may act by rendering hydrophobic areas of contact of the junctional proteins temporarily hydrophilic.
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Bioadhesive microspheres as a potential nasal drug delivery system
TL;DR: In vitro studies using model compounds showed high degrees of loading capacities for the various microspheres systems and it was possible to a certain degree to control the release of the compounds from the microsphere systems.
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A novel in situ method to test polymers and coated microparticles for bioadhesion
K.V.Ranga Rao,Pierre Buri +1 more
TL;DR: In this paper, a simple quantitative and realistic in situ method to test the bioadhesive potential of polymers was developed, in which the glass spheres or drug crystals were first coated with the polymers to be tested.