Journal ArticleDOI
Efficacy and safety profile of anti-interleukin-1 treatment in Behçet’s disease: a multicenter retrospective study
Giacomo Emmi,Rosaria Talarico,Giuseppe Lopalco,Rolando Cimaz,Fabrizio Cantini,Ombretta Viapiana,Ignazio Olivieri,Matteo Goldoni,Antonio Vitale,Elena Silvestri,Domenico Prisco,Giovanni Lapadula,Mauro Galeazzi,Florenzo Iannone,Luca Cantarini +14 more
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TLDR
The data have confirmed that the use of anti-IL-1β drugs is efficacious and safe with an overall acceptable retention on treatment.Abstract:
Growing data have provided encouraging results on the use of interleukin (IL)-1 inhibitors in Behcet’s disease (BD). This study was aimed at reporting the largest experience with anti-IL-1 agents in BD patients. We evaluated 30 BD patients receiving treatment with anti-IL-1 agents. The primary aims of the study were to evaluate the efficacy of anakinra (ANA) and canakinumab (CAN) in a cohort of BD. The secondary aims were to evaluate the overall safety profile of the treatments, explore the timing of response to therapy and any adjustment of dosage and frequency of drugs studied, and investigate predictive factors of response to therapy. The frequency of first line therapy was 90 % with ANA and 10 % with CAN. The overall number of subjects in complete remission after 12 months of therapy with anti-IL-1 drugs was 13: 6 maintained the initial therapy regimen, 1 maintained the same initial anti-IL-1 drug with further therapeutic adjustments, and the remaining 6 shifted from ANA to CAN. Among them, 3 used CAN for at least 12 months without therapeutic adjustments, 1 had therapeutic adjustments, and 3 had an overall history of a 12-month complete remission. Adverse events (AEs) were reported in 15 % patients who received ANA, represented in all cases by local cutaneous reactions, while no AE were observed in patients who received CAN; we did not observe any serious AEs (SAEs) during the follow-up period. Our data have confirmed that the use of anti-IL-1β drugs is efficacious and safe with an overall acceptable retention on treatment.read more
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Journal ArticleDOI
2018 update of the EULAR recommendations for the management of Behçet’s syndrome
Gulen Hatemi,Robin Christensen,Dongsik Bang,Bahram Bodaghi,Aykut Ferhat Celik,Farida Fortune,Julien Gaudric,Ahmet Gül,Ina Kötter,Pietro Leccese,Alfred Mahr,Robert J. Moots,Yesim Ozguler,Jutta G Richter,David Saadoun,Carlo Salvarani,Francesco Scuderi,Petros P. Sfikakis,Aksel Siva,Miles Stanford,Ilknur Tugal-Tutkun,Richard P. West,Sebahattin Yurdakul,Ignazio Olivieri,Hasan Yazici +24 more
TL;DR: The recommendations on the medical management of mucocutaneous, joint, eye, vascular, neurological and gastrointestinal involvement of BS were modified; five overarching principles and a new recommendation about the surgical management of vascular involvement were added.
Journal ArticleDOI
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors)
Kevin L. Winthrop,Xavier Mariette,José Tiago Silva,Esther Benamu,Leonard H. Calabrese,Alexandre Dumusc,Josef S Smolen,José María Aguado,Mario Fernández-Ruiz,Mario Fernández-Ruiz +9 more
TL;DR: The safety profile of agents targeting interleukins, immunoglobulins and complement factors and to suggest preventive recommendations are reviewed, from an Infectious Diseases perspective.
Journal ArticleDOI
Interleukin (IL)-1 inhibition with anakinra and canakinumab in Behçet's disease-related uveitis: a multicenter retrospective observational study.
Claudia Fabiani,Antonio Vitale,Giacomo Emmi,Giuseppe Lopalco,Lorenzo Vannozzi,Silvana Guerriero,Stefano Gentileschi,Daniela Bacherini,Rossella Franceschini,Bruno Frediani,Mauro Galeazzi,Florenzo Iannone,Gian Marco Tosi,Luca Cantarini +13 more
TL;DR: Treatment with IL-1 inhibitors is effective in the management of Behçet’s disease-related uveitis and provides a long-term control of ocular inflammation in refractory and long-lasting cases.
Journal ArticleDOI
Neutrophilic dermatoses: Pathogenesis, Sweet syndrome, neutrophilic eccrine hidradenitis, and Behçet disease
Caroline A. Nelson,Sasha Stephen,Hovik J. Ashchyan,William D. James,Robert G. Micheletti,Misha Rosenbach +5 more
TL;DR: The first article in this continuing medical education series explores the pathogenesis of neutrophilic dermatoses and reviews the epidemiology, clinical and histopathologic features, diagnosis, and management of Sweet syndrome, neutrophobic eccrine hidradenitis, and Behçet disease.
Journal ArticleDOI
Modulation of three key innate immune pathways for the most common retinal degenerative diseases
TL;DR: This review highlights the role of three key immune pathways in the pathophysiology of major retinal degenerative diseases including diabetic retinopathy, age‐related macular degeneration, and rare retinal dystrophies and comprehensively summarize the scientific evidence for immunomodulation as potential treatment strategy.
References
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Journal Article
Criteria for diagnosis of Behçet's disease
Journal ArticleDOI
New insights into the pathogenesis of Behçet's disease.
TL;DR: The promotion of Th17 responses and the suppression of regulatory T cells (Tregs) that were driven by interleukin (IL)-21 production and that correlates with BD activity are demonstrated.
Journal ArticleDOI
Interleukin-1β-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behçet's disease: an open-label pilot study
Ahmet Gül,Ilknur Tugal-Tutkun,Charles A. Dinarello,Leonid L. Reznikov,Bahar Artım Esen,A. M. Mirza,Patrick J. Scannon,Alan M. Solinger +7 more
TL;DR: Well tolerated, XOMA 052 resulted in a rapid onset and sustained reduction in intraocular inflammation in patients with resistant uveitis and retinal vasculitis, and the effect was observed despite discontinuation of immunosuppressive agents and without the need to increase corticosteroid dosages.
Journal ArticleDOI
Behçet's disease as an autoinflammatory disorder.
TL;DR: Delineation of the similarities of Behçet's disease to other hereditary autoinflammatory diseases may help to clarify its pathogenesis and also to identify the missing links in the shared inflammatory pathways.
Journal ArticleDOI
Behçet's syndrome patients exhibit specific microbiome signature
Clarissa Consolandi,Silvia Turroni,Giacomo Emmi,Marco Severgnini,Jessica Fiori,Clelia Peano,Elena Biagi,Alessia Grassi,Simone Rampelli,Elena Silvestri,Manuela Centanni,Fabio Cianchi,Roberto Gotti,Lorenzo Emmi,Patrizia Brigidi,Nicola Bizzaro,Gianluca De Bellis,Domenico Prisco,Marco Candela,Mario Milco D'Elios +19 more
TL;DR: It is reported, for the first time, that a peculiar dysbiosis of the gut microbiota is present in patients with Behçet syndrome and this corresponds to specific changes in microbiome profile.
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2018 update of the EULAR recommendations for the management of Behçet’s syndrome
Gulen Hatemi,Robin Christensen,Dongsik Bang,Bahram Bodaghi,Aykut Ferhat Celik,Farida Fortune,Julien Gaudric,Ahmet Gül,Ina Kötter,Pietro Leccese,Alfred Mahr,Robert J. Moots,Yesim Ozguler,Jutta G Richter,David Saadoun,Carlo Salvarani,Francesco Scuderi,Petros P. Sfikakis,Aksel Siva,Miles Stanford,Ilknur Tugal-Tutkun,Richard P. West,Sebahattin Yurdakul,Ignazio Olivieri,Hasan Yazici +24 more