Showing papers in "Autoimmunity Reviews in 2015"

TL;DR: This review aims at describing the mechanisms involved in the regulation of Zn homeostasis and their effects on the immune response focusing on those which are implicated in the physiopathology of rheumatoid arthritis.

TL;DR: E Epidemiological data suggest that AITD patients should be accurately monitored for thyroid dysfunctions, the appearance of thyroid nodules, and other autoimmune disorders.

TL;DR: It is hypothesized that commonly used industrial food additives abrogate human epithelial barrier function, thus, increasing intestinal permeability through the opened tight junction, resulting in entry of foreign immunogenic antigens and activation of the autoimmune cascade.

TL;DR: SLE is so far the autoimmune disease with the largest number of detectable autoantibodies, and their production could be antigen-driven, the result of a polyclonal B cell activation, impaired apoptotic pathways, or the outcome of an idiotypic network dysregulation.

TL;DR: This review outlines studies describing Treg frequency and suppressive function in systemic and organ specific autoimmune diseases, with a specific focus on the challenges faced when investigating Tregs in these conditions.

TL;DR: This work focuses on the involvement of lncRNA regulation in innate and adaptive immune responses, immune cell development, and differential expression in autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus, multiple sclerosis, autoimmune thyroid disease, psoriasis, polymyositis/dermatomyositis (PM/DM) and Crohn's disease.

TL;DR: Churg-Strauss syndrome (CSS) was first described in 1951 by Churg and Strauss as a rare disease characterized by disseminated necrotizing vasculitis with extravascular granulomas occurring exclusively among patients with asthma and tissue eosinophilia as mentioned in this paper.

TL;DR: The hypothesis that rather than being a disease-dependent process, citrullination is an inflammatory-dependent condition that plays a central role in autoimmune diseases is supported.

TL;DR: It is reported, for the first time, that a peculiar dysbiosis of the gut microbiota is present in patients with Behçet syndrome and this corresponds to specific changes in microbiome profile.

TL;DR: The general aim of this review is to highlight the most recent findings on miRNAs expression profiles in RA patients and to discuss their potential as new biomarkers for diagnostic purposes.

TL;DR: The overall GRADE analysis was very low for migraine and seizures, low for superficial venous thrombosis,Thrombocytopenia, chorea, longitudinal myelitis and the so-called seronegative APS and moderate for APS nephropathy, heart valve lesions and livedo reticularis.

TL;DR: Recent studies suggest that intervention of the JAK pathway may have a potential therapeutic efficacy for AA, and multiple treatment options including the use of broad acting corticosteroids appear to be relatively effective in mild cases.

TL;DR: Treatment of severe involvement in IgA vasculitis remains controversial, with no evidence that corticosteroids or immunosuppressive agents improved long-term outcome, and Prospective, randomized, controlled trials are needed to analyze the benefit-risk ratio of such treatments.

TL;DR: New prospective studies indicate improved outcomes for pregnancies in women with rare diseases like systemic sclerosis and vasculitis and TNF inhibitors hold promise for maintaining remission in rheumatological patients and may be continued at least in the first half of pregnancy.

TL;DR: Thrombosis and progression to SLE in mothers with OAPS are scarce compared with "classical APS", suggesting that they have different aPL-mediated pathogenic mechanisms.

TL;DR: A multidisciplinary expert panel was constituted, and an evidence-based guidance for LTBI detection, identification of the individualized level of risk of TB reactivation, and practical management of patients with TB occurrence was formulated.

TL;DR: The potential of the Google search engine to collect and merge large series of SADs reported in the Pubmed library was explored, with the aim of obtaining a high-definition geoepidemiological picture of each disease.

TL;DR: The study shows the benefit of hydroxychloroquine addition in patients with refractory obstetrical APS and raises the need of prospective studies to confirm the preliminary study.

TL;DR: Posterior reversible encephalopathy syndrome is a rare clinicoradiological entity characterized by typical MRI findings located in the occipital and parietal lobes, caused by subcortical vasogenic edema.

TL;DR: It is suggested that the specific activity of RTX on B-cell-driven autoimmunity might explain its beneficial effects on some particular SSc clinical symptoms, namely the improvement of skin and articular involvement, and possibly the attenuation of lung fibrosis.

TL;DR: Lower vitamin D levels have been found in several autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, type 1 diabetes mellitus, multiple sclerosis, inflammatory bowel diseases, autoimmune thyroid diseases and autoimmune gastritis.

TL;DR: This review summarizes current knowledge concerning the general characteristics of NETs, their antimicrobial properties, and their role in the development of chronic inflammatory processes that underlie the pathogenesis of psoriasis and atherosclerosis.

TL;DR: The diversity of the human placental aPL fingerprint suggests that multiple pathological processes may occur in pregnancies affected by aPL.

TL;DR: The role of IL-27 is discussed in rheumatoid arthritis, multiple sclerosis, colitis, lupus, psoriasis, type 1 diabetes, and uveitis, where it represents a novel, promising target/agent for the treatment of autoimmune diseases.

TL;DR: A better understanding of the above mentioned similarities in the gut-joint inter-relationship, may elucidate additional facets in the mosaic of autoimmunity, relating CD to RA.

TL;DR: The knowledge accumulated over the years from the early evidence of autoreactive CD8 T cells that was studied mainly in the years 1990s and 2000s to the recent findings of the role of Th17, Tc17 cells and γδ T cells in psoriatic disease pathogenesis is reviewed.

TL;DR: In this second largest series of autoimmune high degree CHB, there were unable to find data supporting the routine use of in utero fluorinated steroids, and the use of fluorinate steroids was neither associated with survival nor with regression of 2nd degreeCHB.

TL;DR: Goodpasture's syndrome is a rare and organ-specific autoimmune disease that is mediated by anti-glomerular basement membrane (anti-GBM) antibodies and has pathology characterized by crescentic glomerulonephritis with linear immunofluorescent staining for IgG on the GBM.

TL;DR: The role of cytokines, focusing on TNF-α and antibodies in the depression, is reviewed and it is hypothesized how T NF-α may underlie and mediate the inflammatory process depression in patients with autoimmune disease.

TL;DR: MRI could provide significant clinical information and insights into the pathological substrate of newly diagnosed neuropsychiatric lupus and certain syndromes and immunological patterns are prone to more extensive brain damage.