Journal ArticleDOI
Efficient synthesis of N-2-aryl-1,2,3-triazole fluorophores via post-triazole arylation.
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TLDR
Efficient post-Triazole regioselective N-2 arylation was developed from C-4, C-5 disubstituted-1,2,3-NH-triazoles with excellent yields.About:
This article is published in Organic Letters.The article was published on 2008-11-01. It has received 169 citations till now. The article focuses on the topics: Aryl & Triazole.read more
Citations
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Copper‐Catalyzed Direct C Arylation of Heterocycles with Aryl Bromides: Discovery of Fluorescent Core Frameworks
TL;DR: The reaction shows excellent regioselectivity and exhibits good functional group tolerance, and the 8-aryl xanthines exhibit fluorescence in a variety of solvents and show promise as reagents for biological imaging.
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Triazole−Au(I) Complexes: A New Class of Catalysts with Improved Thermal Stability and Reactivity for Intermolecular Alkyne Hydroamination
TL;DR: Variable-temperature NMR studies revealed dynamic triazole-Au cation coordination in solution, indicating that these new catalysts possess much better thermal stability than literature-reported Au catalysts, including IPrAu x NTf(2).
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Solvent-free synthesis of 1,4-disubstituted 1,2,3-triazoles using a low amount of Cu(PPh3)2NO3 complex
TL;DR: In this paper, an environmentally friendly and highly efficient method for copper-catalyzed cycloaddition of organic azides and terminal alkynes under solvent-free conditions was developed.
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Highly N2-selective palladium-catalyzed arylation of 1,2,3-triazoles.
TL;DR: It is reported that exceptional levels of N2-selectivity can be obtained in the Pd-catalyzed N-arylation of simple 1,2,3-triazoles by the use of a very bulky biaryl phosphine ligand L1.
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Efficient synthesis of E-alpha-haloenones through chemoselective alkyne activation over allene with triazole-Au catalysts.
TL;DR: These results provided the first example for the synthesis of challenging kinetic E-haloenones, and revealed triazole-Au complexes as effective catalysts in promoting chemoselective activation of alkynes over allenes.
References
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Journal ArticleDOI
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.
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Click Chemistry: Diverse Chemical Function from a Few Good Reactions.
TL;DR: In this paper, a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries through heteroatom links (C-X-C), an approach called click chemistry is defined, enabled, and constrained by a handful of nearly perfect "springloaded" reactions.
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The growing impact of click chemistry on drug discovery.
TL;DR: The copper-(I)-catalyzed 1,2,3-triazole formation from azides and terminal acetylenes is a particularly powerful linking reaction, due to its high degree of dependability, complete specificity, and the bio-compatibility of the reactants.
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Modern Synthetic Methods for Copper‐Mediated C(aryl) ? O, C(aryl) ? N, and C(aryl) ? S Bond Formation
Steven V. Ley,Andrew Thomas +1 more
TL;DR: In this article, the authors highlight the recent developments in the copper-mediated (both stoichiometric and catalytic) reactions of aryl boronic acids as reaction partners in both O- and N-arylation.
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Copper in cross-coupling reactions: The post-Ullmann chemistry
TL;DR: A number of methods using various copper complexes and salts to carry out cross-coupling reactions leading to the formation of C heteroatom (C N, C O, C S, C P, C Se), C C, and C metal bonds have been proposed as discussed by the authors.