Elicitation: A biotechnological tool for enhanced production of secondary metabolites in hairy root cultures
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TLDR
This is a comprehensive review about the progress in the elicitation approach to hairy root cultures from 2010 to 2019 and the information provided is valuable and will be of interest for scientists working in this area of plant biotechnology.Abstract:
Elicitation is a possible aid to overcome various difficulties associated with the large-scale production of most commercially important bioactive secondary metabolites from wild and cultivated plants, undifferentiated or differentiated cultures. Secondary metabolite accumulation in vitro or their efflux in culture medium has been elicited in the undifferentiated or differentiated tissue cultures of several plant species by the application of a low concentration of biotic and abiotic elicitors in the last three decades. Hairy root cultures are preferred for the application of elicitation due to their genetic and biosynthetic stability, high growth rate in growth regulator-free media, and production consistence in response to elicitor treatment. Elicitors act as signal, recognized by elicitor-specific receptors on the plant cell membrane and stimulate defense responses during elicitation resulting in increased synthesis and accumulation of secondary metabolites. Optimization of various parameters, such as elicitor type, concentration, duration of exposure, and treatment schedule is essential for the effectiveness of the elicitation strategies. Combined application of different elicitors, integration of precursor feeding, or replenishment of medium or in situ product recovery from the roots/liquid medium with the elicitor treatment have showed improved accumulation of secondary metabolites due to their synergistic effect. This is a comprehensive review about the progress in the elicitation approach to hairy root cultures from 2010 to 2019 and the information provided is valuable and will be of interest for scientists working in this area of plant biotechnology.read more
Citations
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Biotic elicitors: a boon for the in-vitro production of plant secondary metabolites
Rakesh Bhaskar,Louretta Spandhana Eruva Xavier,Giriprasad Udayakumaran,Dharani Shree Kumar,Rashmitha Venkatesh,Praveen Nagella +5 more
TL;DR: The mechanism ofBiotic elicitation and the applications of biotic elicitors like bacterial, fungal, algal elicitors and other polysaccharides extracted from them has been discussed extensively and it has been noted that the addition of bacterial elicitors showed a 94% increase in genistein production while Escherichia coli showed a 9.1-fold increase in diosgenin production.
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Role of Stress and Defense in Plant Secondary Metabolites Production
Humberto Aguirre-Becerra,Ma. Cristina Vázquez-Hernández,Diana Saenz de la O,Aurora Alvarado-Mariana,Ramón G. Guevara-González,Juan Fernando García-Trejo,Ana A. Feregrino-Perez +6 more
TL;DR: The purpose of elicitation is to interact with the biochemical routes in order to produce secondary metabolites in high quantities, usually with negative effects in biomass production or morphology, but increasing plant quality in terms of aroma, taste or color.
Journal ArticleDOI
Responses of in vitro cell cultures to elicitation: regulatory role of jasmonic acid and methyl jasmonate: a review
TL;DR: In this article, a review of the role of in vitro culture conditions on secondary metabolite production is presented, and various elicitor responses on different biochemical and molecular pathways are discussed.
References
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Journal ArticleDOI
Influence of abiotic stress signals on secondary metabolites in plants
TL;DR: This brief review summarizes the influence of different abiotic factors include salt, drought, light, heavy metals, frost etc. on secondary metabolites in plants.
Journal Article
Plant cell elicitation for production of secondary metabolites: A review
TL;DR: The classification of elicitors, their mechanism of action, and applications for the production of phyto-pharmaceuticals from medicinal plants are discussed.
Journal ArticleDOI
Elicitation, an Effective Strategy for the Biotechnological Production of Bioactive High-Added Value Compounds in Plant Cell Factories.
Karla Ramirez-Estrada,Heriberto Vidal-Limon,Diego Hidalgo,Elisabeth Moyano,Marta Golenioswki,Rosa M. Cusidó,Javier Palazon +6 more
TL;DR: The enhancing effects of elicitors on the production of high-added value plant compounds such as taxanes, ginsenosides, aryltetralin lignans and other types of polyphenols are summarized, focusing particularly on the use of a new generation of elicitor such as coronatine and cyclodextrins.
Journal ArticleDOI
Molecular aspects of the early stages of elicitation of secondary metabolites in plants
TL;DR: This review summarizes molecular information available about the early stages of the elicitation process and the mode of action of elicitors and relevant experimental approaches used to study these topics are discussed.
Book ChapterDOI
Production of Secondary Metabolites Using Plant Cell Cultures
TL;DR: In this chapter, the process for obtaining the secondary metabolites from plant cell cultures is represented as a multi-stage strategy, and each link should be described according to specifications of cell cultures or products.