Elimination of Cholesterol in Macrophages and Endothelial Cells by the Sterol 27-Hydroxylase Mechanism COMPARISON WITH HIGH DENSITY LIPOPROTEIN-MEDIATED REVERSE CHOLESTEROL TRANSPORT
Amir Babiker,Olof Andersson,Erik G. Lund,Rui-Juan Xiu,Samir S. Deeb,Ayeleth Reshef,Eran Leitersdorf,Ulf Diczfalusy,Ingemar Björkhem +8 more
TLDR
The results support the contention that the sterol 27-hydroxylase-mediated elimination of cholesterol is more important in macrophages than in endothelial cells.About:
This article is published in Journal of Biological Chemistry.The article was published on 1997-10-17 and is currently open access. It has received 233 citations till now. The article focuses on the topics: Reverse cholesterol transport & Sterol O-acyltransferase.read more
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Oxysterols: modulators of cholesterol metabolism and other processes.
TL;DR: This review comprises a detailed and critical assessment of current knowledge regarding the formation, occurrence, metabolism, regulatory properties, and other activities of oxysterols in mammalian systems.
Journal ArticleDOI
Oxysterols and atherosclerosis
Andrew J. Brown,Wendy Jessup +1 more
TL;DR: There are a number of significant and quite widespread problems with current literature which preclude more than a tentative suggestion that oxysterol have a causal role in atherogenesis, and further studies are necessary to definitively determine the role of oxysterols in atherosclerosis.
Journal ArticleDOI
27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells.
Xuan Fu,John G. Menke,Yuli Chen,Gaochao Zhou,Karen L. MacNaul,Samuel D. Wright,Carl P. Sparrow,Erik G. Lund +7 more
TL;DR: 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload, and is concluded that 27-hydroxycholesterol functionally activated LXR.
Journal ArticleDOI
Sterols and Isoprenoids: Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway
Peter A. Edwards,Johan Ericsson +1 more
TL;DR: Compounds derived from the isoprenoid/cholesterol biosynthetic pathway have recently been shown to have novel biological activities and regulate transcriptional and post-transcriptional events that in turn affect lipid synthesis, meiosis, apoptosis, developmental patterning, protein cleavage, and protein degradation.
Journal ArticleDOI
Regulation of bile acid synthesis
TL;DR: Recent advances in purification and cloning of these major enzymes in the pathways have led to better understanding the molecular basis of regulation of bile acid synthesis and physiological role of the alternative pathways.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
TL;DR: A method has been devised for the electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets that results in quantitative transfer of ribosomal proteins from gels containing urea.
Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA
TL;DR: It is demonstrated that it is possible to culture morphologically and immunologically identifiable human endothelial cells for periods up to 5 mo and ABH antigens appropriate to the tissue donor's blood type were not detectable on cultured smooth muscle cells or fibroblasts.