Journal ArticleDOI
Emerging role of exosomes as biomarkers in cancer treatment and diagnosis
Mohammad Doroudian,E. Y. Krylova +1 more
- Vol. 169, pp 103565-103565
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TLDR
An overview of recent advances in the research of exosomal biomarkers and their applications in cancer diagnosis and treatment has been provided in this article , where the advantages and challenges of using exosomes as liquid biopsy targets are discussed and the clinical implications of using Exosomal miRNAs have been revealed.Abstract:
Cancer is a leading cause of death worldwide and cancer incidence and mortality are rapidly growing. These massive amounts of cancer patients require rapid diagnosis and efficient treatment strategies. However, the currently utilized methods are invasive and cost-effective. Recently, the effective roles of exosomes as promising diagnostic, prognostic, and predictive biomarkers have been revealed. Exosomes are membrane-bound extracellular vesicles containing RNAs, DNAs, and proteins, and are present in a wide array of body fluids. Exosomal cargos have shown the potential to detect various types of cancers at early stages with high sensitivity and specificity. They can also delivery therapeutic agents efficiently. In this article, an overview of recent advances in the research of exosomal biomarkers and their applications in cancer diagnosis and treatment has been provided. Furthermore, the advantages and challenges of exosomes as liquid biopsy targets are discussed and the clinical implications of using exosomal miRNAs have been revealed. read more
Citations
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The role of macrophage subtypes and exosomes in immunomodulation
TL;DR: A review of the role of exosomes in M1/M2-like macrophage polarization and their potential as a promising therapeutic candidate is presented in this article , where the importance of alternatively activated M2 and classically activated M1 macrophages in immune responses and pathological conditions is discussed.
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Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors
TL;DR: In this paper , Mesenchymal stem cells (MSCs) are used to deliver cytotoxic compounds to brain tumor cells and release various vesicles, including exosomes.
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pH-sensitive ameliorated quercetin delivery using graphene oxide nanocarriers coated with potential anticancer gelatin-polyvinylpyrrolidone nanoemulsion with bitter almond oil
Amin Pirali Najafabadi,Mehrab Pourmadadi,Fatemeh Yazdian,Hamid Rashedi,Abbas Rahdar,Ana M. Díez-Pascual +5 more
TL;DR: In this article , a dual nano-emulsion water/oil/water with bitter almond oil was developed as a membrane around the nanocomposite to control further drug release, and the resulting pH-sensitive drug delivery system showed an 87.5% encapsulation efficiency and a 45% drug loading.
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Exosome nanovesicles: A potential carrier for therapeutic delivery
Vivek P. Chavda,Anjali Pandya,Lalit Kumar,Nidhi Raval,Lalitkumar K. Vora,Sreeranjini Pulakkat,Vandana B. Patravale,Salwa,Yanhong Duo,B. Tang +9 more
TL;DR: A comprehensive overview of the recent advances in exosome nanotechnology research, including their classification, isolation and preparation, constitution, biological function, and nanobiomedical applications in disease treatment and diagnosis is provided in this paper .
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Molecular Insight into the Therapeutic Effects of Stem Cell-Derived Exosomes in Respiratory Diseases and the Potential for Pulmonary Delivery
TL;DR: The literature discussing the therapeutic effects of SC-Exos against respiratory diseases and advances in the pulmonary route of delivery of these exosomes to the damaged tissues are reviewed.
References
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Journal ArticleDOI
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung,Jacques Ferlay,Rebecca L. Siegel,Mathieu Laversanne,Isabelle Soerjomataram,Ahmedin Jemal,Freddie Bray +6 more
TL;DR: The GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer (IARC) as mentioned in this paper show that female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung cancer, colorectal (11 4.4%), liver (8.3%), stomach (7.7%) and female breast (6.9%), and cervical cancer (5.6%) cancers.
Journal ArticleDOI
Cancer statistics, 2019.
TL;DR: The overall cancer death rate dropped continuously from 1991 to 2016 by a total of 27%, translating into approximately 2,629,200 fewer cancer deaths than would have been expected if death rates had remained at their peak.
Journal ArticleDOI
Oncology Meets Immunology: The Cancer-Immunity Cycle
TL;DR: Emerging clinical data suggest that cancer immunotherapy is likely to become a key part of the clinical management of cancer and may be more effective in combination with agents that target other steps of the cycle.
Journal ArticleDOI
The biology, function, and biomedical applications of exosomes
TL;DR: The intrinsic properties of exosomes in regulating complex intracellular pathways has advanced their potential utility in the therapeutic control of many diseases, including neurodegenerative conditions and cancer.
Journal ArticleDOI
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Sonia A. Melo,Linda B. Luecke,Christoph Kahlert,Agustín F. Fernández,Seth T. Gammon,Judith Kaye,Valerie S. LeBleu,Elizabeth A. Mittendorf,Juergen Weitz,Nuh N. Rahbari,Christoph Reissfelder,Christian Pilarsky,Mario F. Fraga,David Piwnica-Worms,Raghu Kalluri +14 more
TL;DR: GPC1+ crExos may serve as a potential non-invasive diagnostic and screening tool to detect early stages of pancreatic cancer to facilitate possible curative surgical therapy.