Journal ArticleDOI
Enaminones: versatile intermediates for natural product synthesis*
Joseph P. Michael,C. B. De Koning,David Gravestock,Gladys D. Hosken,Arthur S. Howard,C. M. Jungmann,Rui W. M. Krause,Andrew S. Parsons,Stephen C. Pelly,Trevor V. Stanbury +9 more
TLDR
In this article, an overview of the chemistry of enaminones and related compounds containing the structural unit N-CaC-Z (Za COR, CO2R, CN, NO2, S O 2Ar, etc.).Abstract:
Efforts in our laboratories to devise a general approach to the synthesis of alkaloids focus on the versatile reactivity of enaminones and related compounds containing the structural unit N-CaC-Z (Za COR, CO2R, CN, NO2 ,S O 2Ar, etc.). This lecture presents an overview of our research with these useful building blocks. Themes to be elaborated include chemo- selectivity and diastereoselectivity in reactions of enaminones, and the challenge of controlling absolute stereochemistry.read more
Citations
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Journal ArticleDOI
(Z)-Methyl 3-(4-ethoxy-anilino)but-2-enoate.
TL;DR: The title compound, C13H17NO3, was synthesized from methyl 3-oxobutanoate and 4-ethoxybenzenamine using a catalytic amount of InBr3 under solvent-free conditions.
Journal ArticleDOI
Sulfated Polyborate Catalyzed Improved Synthesis of Enamines and Enaminones Based Intermediates of Imatinib, Nilotinib and Ocinaplon**
TL;DR: In this article , an activation of methyl ketones or active methylenes and N, N-dimethylformamide dimethyl acetal at 110 °C by sulfated polyborate under solvent-free conditions has been developed for enamines and enaminones synthesis.
Journal ArticleDOI
Crystal and molecular structures of (3Z)-(±)-4-(2′-hydroxypropyl)amino-and (3Z)-4-(2′-hydroxyethyl)amino-pent-3-en-2-ones
TL;DR: In this article, an X-ray study of (3Z)-(±)-4-(2′-hydroxypropyl)amino and (3z)-4(2′)-amino-pent-3-en-2-ones is reported.
Journal ArticleDOI
Synthesis, molecular structure, conformational, and intramolecular hydrogen bond strength of ethyl 3-amino-2-butenoate and its N-Me, N-Ph, and N-Bn analogs; an experimental and theoretical study
Mahmoud Bazrafshan,Mohammad Vakili,Sayyed Faramarz Tayyari,Fadhil S. Kamounah,Poul Erik Hansen,Ali Shiri +5 more
TL;DR: In this article , the molecular structures and IHB strength of the title molecules are studied using computational analysis (density functional theory, DFT, methods) at the B3LYP/6-311++G(d,p) level and spectroscopic techniques (IR, UV and NMR).
References
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BookDOI
Alkaloids : chemical and biological perspectives
TL;DR: In this paper, the total synthesis of amaryllidaceae alkaloids has been studied using radical cyclization reactions in total syntheses of naturally occurring indole alkaloid.
Book
Strategies and Tactics in Organic Synthesis
TL;DR: This paper presents the first total Synthesis of several Natural Products Based On Alkyne-Co2(Co2)6 Complexes, and discusses the design and synthesis of Cooperative "Pinwheel" Fluorescent Sensors, and the application of Silicon-Ass Intramolecular Cross-Coupling.