Journal ArticleDOI
Enantioselective total synthesis of (-)-alpha-kainic acid.
Andreas Farwick,Günter Helmchen +1 more
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TLDR
An enantioselective total synthesis of (-)-alpha-kainic acid is described, which involves an Ir-catalyzed allylic amination with a propargylic amine to provide an enyne and a diastereoselectives intramolecular Pauson-Khand reaction.About:
This article is published in Organic Letters.The article was published on 2010-02-11. It has received 87 citations till now. The article focuses on the topics: Amination & Silyl ether.read more
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Journal ArticleDOI
Iridium-Catalyzed Asymmetric Allylic Substitution Reactions
TL;DR: In this review, an explicit outline of ligands, mechanism, scope of nucleophiles, and applications is presented, including ligand development, mechanistic understanding, substrate scope, and application in the synthesis of complex functional molecules.
Journal ArticleDOI
Applications of Iridium-Catalyzed Asymmetric Allylic Substitution Reactions in Target-Oriented Synthesis
Jian-Ping Qu,Günter Helmchen +1 more
TL;DR: The iridium-catalyzed allylic substitution with subsequent ring closing metathesis is a powerful strategy for their synthesis, and some fairly complex targets, for example, the potent nitric oxide inhibitor and the drug (-)-protrifenbute, have been synthesized via less than five steps from simple starting materials.
Journal ArticleDOI
Phosphoramidite Gold(I)-Catalyzed Diastereo- and Enantioselective Synthesis of 3,4-Substituted Pyrrolidines
TL;DR: In this article the utility of phosphoramidite ligands in enantioselective Au(I) catalysis was explored in the development of highly diastereo- and enantiOSElective au(I)-catalyzed cycloadditions of allenenes in order to support the construction of three contiguous stereogenic centers.
Journal ArticleDOI
Recent advances and applications of iridium-catalysed asymmetric allylic substitution
TL;DR: An overview of the development of iridium catalysts derived from an Ir salt and a chiral phosphoramidite and their application to the enantioselective synthesis of natural products and biologically relevant compounds is provided.
Book ChapterDOI
Iridium-Catalyzed Asymmetric Allylic Substitution
TL;DR: In this article, the authors discuss the mechanistic investigation, reaction scope, and synthetic application of Ir-catalyzed asymmetric allylic substitution reactions and classify them according to different types of nucleophiles such as C, N, O, and S.
References
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Journal ArticleDOI
Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea.
Joseph T. Coyle,Robert Schwarcz +1 more
TL;DR: It is reported that the injection of kainic acid into the rat striatum causes neuronal degeneration, neurochemical alterations and behavioural responses resembling Huntington's chorea, which could provide an animal model for the study of the disease.
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Tetrapropylammonium Perruthenate, Pr4N+RuO4-, TPAP: A Catalytic Oxidant for Organic Synthesis
TL;DR: In this paper, a review of the oxidations of a wide range of molecules with tetrapropylammonium perruthenate including examples of both double oxidations and selective oxidations is presented.
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Structure-activity relationships in the development of excitatory ammo acid receptor agonists and competitive antagonists
TL;DR: The chemical features and SARs of agonists and antagonists, particularly those features associated with subtype selectivity, are described in this double-length review.
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