Journal ArticleDOI
Enhancement of misonidazole radiosensitization by an inhibitor of glutathione biosynthesis.
TLDR
In this article, the enhancement of Misonidazole radiosensitization by an inhibitor of Glutathione Biosynthesis was discussed, and the effects of the inhibitor on the Glutathi biosynthesis were investigated.Abstract:
(1983). Enhancement of Misonidazole Radiosensitization by an Inhibitor of Glutathione Biosynthesis. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine: Vol. 43, No. 2, pp. 179-183.read more
Citations
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Journal ArticleDOI
Selective modification of glutathione metabolism
TL;DR: Modifications of glutathione metabolism may be achieved by administration of selective enzyme inhibitors, and also by giving compounds that increase glutATHione synthesis, which are useful in chemotherapy and radiation therapy and in protecting cells against the toxic effects of drugs, other foreign compounds, and oxygen.
Journal Article
Glutathione Metabolism as a Determinant of Therapeutic Efficacy: A Review
Bradley A. Arrick,Carl Nathan +1 more
TL;DR: It seems likely that alterations in glutathione metabolism of tumor or host as a result of one therapeutic intervention may affect the outcome of concurrent treatments, and knowledge of these interactions may be useful in designing combination therapy for neoplastic disease.
Journal ArticleDOI
Chemical Radiosensitizers for Use in Radiotherapy
TL;DR: A wide variety of drugs that influence the nature or repair of DNA damage are being evaluated in conjunction with radiation; it is often difficult to define the mechanisms underlying chemoradiation regimens.
Journal ArticleDOI
Role of glutathione in the radiation response of mammalian cells in vitro and in vivo.
TL;DR: In principle, modification of DNA repair could have a greater impact on radiation therapy than modification of the number of lesions produced by radiation.
Journal ArticleDOI
Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice
TL;DR: Administration of L-BSO to preweanling mice provides a novel model system for the induction of cataracts by depletion of lens glutathione and may enable the study of critical functions of glutATHione in the lens and other growing tissues during early postnatal development.
References
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Journal ArticleDOI
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).
O.W. Griffith,A. Meister +1 more
TL;DR: The findings support the conclusion that the S-alkyl moiety of the sulfoximine binds at the enzyme site that normally binds the acceptor amino acid and increases in a manner which is parallel to those of the corresponding isosteric accepter amino acid substrates, i.e. glycine, alanine, and alpha-aminobutyrate.
Book ChapterDOI
The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.
TL;DR: The knowledge of the way in which mutagens and carcinogens are metabolized is essential to a better understanding of their mode of action and of the processes for their detoxication.
Journal ArticleDOI
A colorimetric method for determining low concentrations of mercaptans.
TL;DR: A study of the specificity of the reaction indicates that it occurs only with the S − group (actual or potential, as in thiourea), and heavy-metal ions interfere with the reaction by irreversibly bonding any S − ions.
Journal ArticleDOI
Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers.
TL;DR: Radiosensitization efficiencies for seven different 2-nitroimidazoles including Ro-07-0582 and its urinary metabolite, Ro-05-9963, and two 5-nitrogen-containing compounds, including metronidazole, have been determined in hypoxic Chinese Hamster cells, line V79-379A, X-irradiated in vitro.
Journal ArticleDOI
Glutathione contents of tissues in the aging mouse.
G A Hazelton,C A Lang +1 more
TL;DR: Results extend the previous results and indicate that a general characteristic of aging tissues may be a decrease in GSH concentrations, consistent with the hypothesis that the reducing potential of tissues decreases in senescence.
Related Papers (5)
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).
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EA Bump,Ning Y. Yu,JM Brown +2 more