Journal ArticleDOI
Environmental stress as a factor in the response of rat brain catecholamine metabolism to Δ8-tetrahydrocannabinol
TLDR
It is suggested that some of the behavioural effects of cannabis administered under stressful conditions may be related to alterations in striatal dopamine metabolism, which is consistent with increased dopamine reuptake in striatum produced by this combination of THC and novel environment.About:
This article is published in European Journal of Pharmacology.The article was published on 1977-01-21. It has received 32 citations till now. The article focuses on the topics: Dopamine & Tetrahydrocannabinol.read more
Citations
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Journal ArticleDOI
Gene-Environment Interplay Between Cannabis and Psychosis
TL;DR: Evidence suggests that mechanisms of gene-environment interaction are likely to underlie the association between cannabis and psychosis, and multiple variations within multiple genes--rather than single genetic polymorphisms--together with other environmental factors may interact with cannabis to increase the risk of psychosis.
Journal ArticleDOI
The effects of Δ9-tetrahydrocannabinol on the dopamine system.
Michael A P Bloomfield,Abhishekh Hulegar Ashok,Abhishekh Hulegar Ashok,Nora D. Volkow,Oliver D. Howes,Oliver D. Howes +5 more
TL;DR: The effects of Δ9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, are a pressing concern for global mental health and there is conflicting evidence from human and animal studies concerning the effects of THC on the dopamine system.
Journal ArticleDOI
Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala.
TL;DR: The CeA is an important neural substrate subserving the interactions between cannabinoids and environmental stress, and could be relevant to understanding the context-dependent emotional and affective changes induced by marijuana intoxication and the role of endocannabinoid signaling in the modulation of amygdalar activity.
Journal ArticleDOI
Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines.
Rebecca Kuepper,Paul D. Morrison,Jim van Os,Jim van Os,Robin M. Murray,Gunter Kenis,Cécile Henquet +6 more
TL;DR: It is concluded that further study of the mechanisms underlying the link between cannabis and psychosis may be conducted productively from the perspective of progressive developmental sensitization, resulting from gene-environment interactions.
References
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Journal ArticleDOI
Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.
TL;DR: It is revealed that norepinephrine and dopamine are specifically localized in complex systems of neurons in the brain, a finding which lends support to the hypothesis that both amines may be neurotransmitters in the central nervous system.
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The fluorometric assay of catecholamines and related compounds: improvements and extensions to the hydroxyindole technique.
R. Laverty,K.M. Taylor +1 more
TL;DR: A fluorometric hydroxyindole assay method for a wide range of catecholamines and related compounds has been developed based on iodine oxidation, alkaline rearrangement, and subsequent measurement of the fluorescence of the final solution at an acid pH.
Journal Article
Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas
TL;DR: In the rat cerebral cortex, d -amphetamine was 10-fold more potent an inhibitor of dl -H3-norepinephrine uptake than l -amphetamine; however, in the rat corpus striatum, d- and l - methamphetamine were equipotent as inhibitors of H3-dopamine uptake.
Journal Article
Identification and chemical assay of norepinephrine in brain and other tissues.
TL;DR: Norepinephrine has been identified chemically as a normal constituent of brain and a simple, rapid fluorometric method for the estimation of catechol amines in brain and other tissues is described.
Journal ArticleDOI
Central effects of an inhibitor of tyrosine hydroxylation.
H. Corrodi,L. C. F. Hanson +1 more
TL;DR: A small dose of d-DOPA refills the dopamine and noradrenaline storage sites in the brain of animals pretreated with H 44/68 and causes an improvement in the conditioned avoidance response.