Journal ArticleDOI
Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an ecuadoran poison frog
Thomas F. Spande,H. M. Garraffo,M. W. Edwards,Herman J. C. Yeh,Lewis K. Pannell,John W. Daly +5 more
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TLDR
A potent non-opioid analgesic, epibatidine, has been isolated from skins of the Ecuadoran poison frog, Epipedobates tricolor, and its structure determined by MS, IR, and 1 H NMR analyses as exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane represents a unique new class of alkaloids.Abstract:
A potent non-opioid analgesic, epibatidine, has been isolated from skins of the Ecuadoran poison frog, Epipedobates tricolor, and its structure determined by MS, IR, and 1 H NMR analyses as exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane. It represents a unique new class of alkaloidsread more
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Monosomic Analysis of F2 Poros-monos x M30 against Powdery Mildew (Erysiphe graminis f. sp. Tritici marchal)
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Chemical Diversity in Nature Produces Potent Drugs of Various Ailments; Natural Products
TL;DR: Nature is a unique source of structures of high phytochemical diversity, many of them possessing interesting pharmacological activities and medicinal properties, and natural products remain a prominent source for the discovery of new drugs and drug leads even from Vedic period.
Drug synthesis methods and manufacturing technology preparative-scale production of the analgesic (2r*)-2-(6-chloropyridin-3-yl)-7-azabicyclo(2.2.1)heptane (epibatidine)
TL;DR: A preparative-scale method was developed for the production of the analgesic epibatidine, yielding its endo and exo isomers with yields of 9.9% and 8.8% respectively.
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Autoradiographical studies with the somatostatin sst(2)-receptor-selective novel radioligand [I-125]-BIM-23027 in rat brain [Abstract]
OtherDOI
Cholinergics/Anticholinergics/Muscarinics/Nicotinics
TL;DR: The cholinergic nervous system and the structures of muscarinic and nicotinic receptors are summarized and attempts to develop of drugs selective for one of the five Muscarinic receptors, both agonist and antagonists are discussed.