Journal ArticleDOI
Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an ecuadoran poison frog
Thomas F. Spande,H. M. Garraffo,M. W. Edwards,Herman J. C. Yeh,Lewis K. Pannell,John W. Daly +5 more
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TLDR
A potent non-opioid analgesic, epibatidine, has been isolated from skins of the Ecuadoran poison frog, Epipedobates tricolor, and its structure determined by MS, IR, and 1 H NMR analyses as exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane represents a unique new class of alkaloids.Abstract:
A potent non-opioid analgesic, epibatidine, has been isolated from skins of the Ecuadoran poison frog, Epipedobates tricolor, and its structure determined by MS, IR, and 1 H NMR analyses as exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane. It represents a unique new class of alkaloidsread more
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Indolizidine and quinolizidine alkaloids
TL;DR: This review covers the isolation, structure determination, synthesis, chemical transformations and biological activity of indolizidine and quinolIZidine alkaloids.
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The natural production of chlorinated compounds.
TL;DR: It is suggested that organic compounds containing covalently bound halogens are found only infre quently in living organisms and that natural pro cesses have been a vi tal c o m p o nent of the authors' ecosystem for eons.
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Thirty Years of Discovering Arthropod Alkaloids in Amphibian Skin
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Smoking and pain: pathophysiology and clinical implications.
TL;DR: In this article, the authors examined current knowledge regarding how acute and chronic exposure to nicotine and cigarette smoke affects chronic pain conditions, and explored the association of cigarette smoking with chronic painful conditions and potential mechanisms to explain this association.