Journal ArticleDOI
Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an ecuadoran poison frog
Thomas F. Spande,H. M. Garraffo,M. W. Edwards,Herman J. C. Yeh,Lewis K. Pannell,John W. Daly +5 more
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TLDR
A potent non-opioid analgesic, epibatidine, has been isolated from skins of the Ecuadoran poison frog, Epipedobates tricolor, and its structure determined by MS, IR, and 1 H NMR analyses as exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane represents a unique new class of alkaloids.Abstract:
A potent non-opioid analgesic, epibatidine, has been isolated from skins of the Ecuadoran poison frog, Epipedobates tricolor, and its structure determined by MS, IR, and 1 H NMR analyses as exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane. It represents a unique new class of alkaloidsread more
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Binding and sequestration of poison frog alkaloids by a plasma globulin
Aurora Alvarez-Buylla,Maria Dolores Moya-Garzon,Alexandra E. Rangel,Elicio Tapia,Julia T. Tanzo,H. Tom Soh,Luis A. Coloma,Jonathan Z. Long,Lauren A. O’Connell +8 more
TL;DR: In this article , a liver-derived alkaloid-binding globulin (ABG) was found to be a member of the serine-protease inhibitor (serpin) family.
Journal ArticleDOI
Construction of 2‐Azabicyclo[2.2.1]heptenes via Selenium‐Catalyzed Intramolecular Oxidative Amination of Cyclopentenes
Alin Fumurescu,Imran Hassan +1 more
TL;DR: In this paper , a selenium-catalyzed intramolecular oxidative amination of cyclopentenes has been described, and a variety of 2-azabicyclo[2.2.1]heptenes were obtained with 58%-96% yields.
Journal ArticleDOI
A facile synthesis of enantiopure 7-benzyloxycarbonyl-7-azabicyclo[2.2.1]heptane-2-carboxylic acid
TL;DR: An efficient procedure for the preparation of enantiopure 7-benzyloxycarbonyl-7-azabicyclo[2.2.1]heptane-2-carboxylic acids is described in this paper.