Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: A systematic review
TLDR
Incidence and prevalence rates of both PSC and PBC vary widely and seem to be increasing, therefore large population-based studies combining meticulous case-finding and case-ascertainment strategies are necessary.About:
This article is published in Journal of Hepatology.The article was published on 2012-05-01 and is currently open access. It has received 505 citations till now. The article focuses on the topics: Prevalence & Incidence (epidemiology).read more
Citations
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Burden of liver diseases in the world
TL;DR: The global prevalence of viral hepatitis remains high, while drug-induced liver injury continues to increase as a major cause of acute hepatitis.
Journal ArticleDOI
Primary sclerosing cholangitis
TL;DR: The role of environmental factors in generation of lymphocytes that are postulated to be retargeted, deleteriously, to the biliary tree has been investigated in this paper.
Journal ArticleDOI
Epidemiology of primary Sjögren's syndrome: a systematic review and meta-analysis
TL;DR: A systematic review of the epidemiology of primary Sjögren's syndrome to assess the prevalence rates (PRs) and incidence rates (IRs), and to investigate possible geographic variations in pSS to better understand the global epidemiology.
Journal ArticleDOI
Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis.
Kirsten Boonstra,Rinse K. Weersma,Karel J. van Erpecum,Erik A.J. Rauws,B W Marcel Spanier,Alexander C. Poen,Karin M.J. van Nieuwkerk,Joost P.H. Drenth,Ben J.M. Witteman,H.A.R.E. Tuynman,Anton H. Naber,Paul J. Kingma,Henk R. van Buuren,Bart van Hoek,Frank P. Vleggaar,Nan van Geloven,Ulrich Beuers,Cyriel Y. Ponsioen +17 more
TL;DR: This study exemplifies that, for relatively rare diseases, it is paramount to collect observational data from large, population‐based cohorts, because incidence and prevalence rates of PSC are markedly lower and survival much longer than previously reported.
Journal ArticleDOI
Contemporary Epidemiology of Chronic Liver Disease and Cirrhosis
TL;DR: Although vaccination, screening, and anti-viral treatment campaigns for hepatitis B and C have reduced CLD burden in some parts of the world, concomitant increases in injection drug use, alcohol misuse and metabolic syndrome threaten these trends.
References
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Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal ArticleDOI
Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis.
Ulrika Broomé,R Olsson,Lars Lööf,G Bodemar,Rolf Hultcrantz,Åke Danielsson,Hanne Prytz,Hanna Sandberg-Gertzén,S Wallerstedt,Greger Lindberg +9 more
TL;DR: It was found that age, serum bilirubin concentration, and histological stage at the time of diagnosis were independent predictors of a bad prognosis, which should be of value for the timing of transplantation and patient counselling in PSC.
Journal ArticleDOI
Hepatic and extrahepatic malignancies in primary sclerosing cholangitis.
Annika Bergquist,Anders Ekbom,R Olsson,Dan Kornfeldt,Lars Lööf,Åke Danielsson,Rolf Hultcrantz,Stefan Lindgren,Hanne Prytz,Hanna Sandberg-Gertzén,Sven Almer,Fredrik Granath,Ulrika Broomé +12 more
TL;DR: The frequency of cholangiocarcinoma is 13% and the risk of hepatobiliary carcinoma is constant after the first year after PSC diagnosis with an incidence rate of 1.5% per year, suggestive of an increased risk of pancreatic carcinoma in patients with PSC.
Journal ArticleDOI
High Dose Ursodeoxycholic Acid for the Treatment of Primary Sclerosing Cholangitis
Keith D. Lindor,Kris V. Kowdley,Velimir A. Luketic,M. Edwyn Harrison,Timothy M. McCashland,Alex S. Befeler,Denise M. Harnois,Roberta A. Jorgensen,Jan Petz,Jill C. Keach,Jody Mooney,Carol Sargeant,Tamara Bernard,Debra King,Ellen Miceli,Jeff Schmoll,Tanya L. Hoskin,Prabin Thapa,Felicity Enders +18 more
TL;DR: Long‐term, high‐dose UDCA therapy is associated with improvement in serum liver tests in PSC but does not improve survival and was associated with higher rates of serious adverse events.
Journal ArticleDOI
Ursodiol for Primary Sclerosing Cholangitis
TL;DR: Ursodiol (ursodeoxycholic acid) benefits patients with primary biliary cirrhosis, another cholestatic liver disease, and well-documented primary sclerosing cholangitis in a randomized, double-blind study comparing ursodiol with placebo.
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Keith D. Lindor,Kris V. Kowdley,Velimir A. Luketic,M. Edwyn Harrison,Timothy M. McCashland,Alex S. Befeler,Denise M. Harnois,Roberta A. Jorgensen,Jan Petz,Jill C. Keach,Jody Mooney,Carol Sargeant,Tamara Bernard,Debra King,Ellen Miceli,Jeff Schmoll,Tanya L. Hoskin,Prabin Thapa,Felicity Enders +18 more