Epidermal Growth Factor Receptor and Transforming Growth Factor-β Signaling Contributes to Variation for Wing Shape in Drosophila melanogaster
Ian Dworkin,Greg Gibson +1 more
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TLDR
In this article, 50 insertional mutations, representing 43 loci in the RTK, Hedgehog, TGF-β pathways, and their genetically interacting factors were used to study the role of these networks on wing shape.Abstract:
Wing development in Drosophila is a common model system for the dissection of genetic networks and their roles during development. In particular, the RTK and TGF-β regulatory networks appear to be involved with numerous aspects of wing development, including patterning, cell determination, growth, proliferation, and survival in the developing imaginal wing disc. However, little is known as to how subtle changes in the function of these genes may contribute to quantitative variation for wing shape, per se. In this study 50 insertional mutations, representing 43 loci in the RTK, Hedgehog, TGF-β pathways, and their genetically interacting factors were used to study the role of these networks on wing shape. To concurrently examine how genetic background modulates the effects of the mutation, each insertion was introgressed into two wild-type genetic backgrounds. Using geometric morphometric methods, it is shown that the majority of these mutations have profound effects on shape but not size of the wing when measured as heterozygotes. To examine the relationships between how each mutation affects wing shape hierarchical clustering was used. Unlike previous observations of environmental canalization, these mutations did not generally increase within-line variation relative to their wild-type counterparts. These results provide an entry point into the genetics of wing shape and are discussed within the framework of the dissection of complex phenotypes.read more
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Systematics of Pipizini and taxonomy of European Pipiza Fallen: molecular and morphological evidence (Diptera, Syrphidae)
TL;DR: The systematics of Pipizini and taxonomy of European Pipiza Fallén and molecular and morphological evidence (Diptera, Syrphidae) are described.
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Body size in Drosophila: genetic architecture, allometries and sexual dimorphism.
TL;DR: The results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific.
Book ChapterDOI
The Use of Geometric Morphometrics in Studying Butterfly Wings in an Evolutionary Ecological Context
TL;DR: The variety of uses to which geometric morphometrics can be applied to understand the effects of the environment on possibly adaptive butterfly wing size and shape variation in ecologically relevant contexts are illustrated.
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Optomotor-blind suppresses instability at the A/P compartment boundary of the Drosophila wing
Jie Shen,Christian Dorner,Christian Dorner,Angela Bahlo,Gert O. Pflugfelder,Gert O. Pflugfelder +5 more
TL;DR: It is shown that omb is required in P cells to prevent aberrant apical fold formation at the A/P boundary of the larval wing disc and cleft formation in the adult wing blade.
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C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.
TL;DR: It is proposed that C-terminal Src Kinase and its SFK substrates impinge upon homeostatic control of NMJ function by regulating downstream expression or localization of FasII.
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