Epidermal growth factor signaling in transformed cells
TLDR
This chapter provides an overview of key mechanisms contributing to aberrant EGFR/ErbB signaling in transformed cells, which results in many phenotypic changes associated with the earliest stages of tumor formation, including several hallmarks of epithelial-mesenchymal transition (EMT).Abstract:
Members of the epidermal growth factor receptor (EGFR/ErbB) family play a critical role in normal cell growth and development. However, many ErbB family members, especially EGFR, are aberrantly expressed or deregulated in tumors and are thought to play crucial roles in cancer development and metastatic progression. In this chapter, we provide an overview of key mechanisms contributing to aberrant EGFR/ErbB signaling in transformed cells, which results in many phenotypic changes associated with the earliest stages of tumor formation, including several hallmarks of epithelial-mesenchymal transition (EMT). These changes often occur through interaction with other major signaling pathways important to tumor progression, causing a multitude of transcriptional changes that ultimately impact cell morphology, proliferation, and adhesion, all of which are crucial for tumor progression. The resulting mesh of signaling networks will need to be taken into account as new regimens are designed for targeting EGFR for therapeutic intervention. As new insights are gained into the molecular mechanisms of cross talk between EGFR signaling and other signaling pathways, including their roles in therapeutic resistance to anti-EGFR therapies, a continual reassessment of clinical therapeutic regimes and strategies will be required. Understanding the consequences and complexity of EGF signaling and how it relates to tumor progression is critical for the development of clinical compounds and establishing clinical protocols for the treatment of cancer.read more
Citations
More filters
Journal ArticleDOI
RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression.
Setareh Rezatabar,Ansar Karimian,Ansar Karimian,Vahid Rameshknia,Vahid Rameshknia,Hadi Parsian,Maryam Majidinia,Tayebeh Azramezani Kopi,Anupam Bishayee,Ali Sadeghinia,Mehdi Yousefi,Mohsen Monirialamdari,Bahman Yousefi +12 more
TL;DR: In this paper, the authors comprehensively discuss the critical function of MAPK signaling in oxidative stress, DNA damage, and cancer progression, and demonstrate that the MEK/ERK pathway is associated with the suitable performance of cellular DNA damage response (DDR), the main pathway of tumor suppression.
Journal ArticleDOI
Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway.
Weiwei Sheng,Chuanping Chen,Ming Dong,Guosen Wang,Jianping Zhou,He Song,Yang Li,Jian Zhang,Shuangning Ding +8 more
TL;DR: Whether CRT promotes EGF-induced epithelial–mesenchymal transition (EMT) in PC via Integrin/EGFR-ERK/MAPK signaling pathway, which would be a promising therapy target for PC is investigated.
Journal ArticleDOI
Glucocorticoids, genes and brain function
TL;DR: A review of microarray reports revealed 88 genes whose transcription is consistently regulated by glucocorticoids (GCs), such as cortisol, corticosterone and dexamethasone, in the brain this article.
Journal ArticleDOI
Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation
TL;DR: The complex persistence of HCMV is reviewed with consideration of latent reservoirs, viral determinants and their host interactions, and host signaling and the control of cellular and viral gene expression that contributes to the establishment of and reactivation from latency.
Journal ArticleDOI
Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.
Jason Buehler,Sebastian Zeltzer,Justin M. Reitsma,Alex Petrucelli,Mahadevaiah Umashankar,Michael Rak,Patricia Zagallo,Joyce A. Schroeder,Scott S. Terhune,Felicia Goodrum +9 more
TL;DR: It is suggested that CMV insulates active EGFR in the cell and that pUL135 and pUL138 function to fine-tune EGFR levels at the cell surface to allow the infected cell to respond to extracellular cues.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2
Dennis J. Slamon,Brian Leyland-Jones,Steven Shak,Hank Fuchs,Virginia E. Paton,Alex Bajamonde,Thomas Fleming,Wolfgang Eiermann,Janet M. Wolter,Mark D. Pegram,José Baselga,Larry Norton +11 more
TL;DR: The addition of trastuzumab to chemotherapy was associated with a longer time to disease progression, a higher rate of objective response, a longer duration of response, and a lower rate of death at 1 year.
Journal ArticleDOI
Molecular mechanisms of epithelial–mesenchymal transition
TL;DR: The reprogramming of gene expression during EMT, as well as non-transcriptional changes, are initiated and controlled by signalling pathways that respond to extracellular cues, and the convergence of signalling pathways is essential for EMT.
Related Papers (5)
Feedback regulation of EGFR signalling: decision making by early and delayed loops.
Roi Avraham,Yosef Yarden +1 more
Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery
A Dokala,Suman S. Thakur +1 more