Journal ArticleDOI
Ergosterol biosynthesis pathway in Aspergillus fumigatus.
Laura Alcazar-Fuoli,Emilia Mellado,Guillermo Garcia-Effron,Jordi F. Lopez,Joan O. Grimalt,J. Manuel Cuenca-Estrella,Juan L. Rodriguez-Tudela +6 more
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TLDR
The analysis of the sterol composition in mutant strains of Aspergillus fumigatus led to a better understanding of the ergosterol biosynthesis pathway in this important fungus.About:
This article is published in Steroids.The article was published on 2008-03-01. It has received 127 citations till now. The article focuses on the topics: Ergosterol & Sterol.read more
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Journal ArticleDOI
A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus
Sven D. Willger,Srisombat Puttikamonkul,Kwang-Hyung Kim,James B. Burritt,Nora Grahl,Laurel J. Metzler,Robert J. Barbuch,Martin Bard,Christopher B. Lawrence,Robert A. Cramer +9 more
TL;DR: These findings present a new function of SREBP proteins in filamentous fungi, and demonstrate for the first time that hypoxia adaptation is likely an important virulence attribute of pathogenic molds.
Journal ArticleDOI
SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus.
Michael Blatzer,Bridget M. Barker,Sven D. Willger,Nicola Beckmann,Sara J. Blosser,Elizabeth J. Cornish,Aurélien J. Mazurie,Nora Grahl,Hubertus Haas,Robert A. Cramer +9 more
TL;DR: It is concluded that the fungal SREBP, SrbA, is critical for coordinating genes involved in iron acquisition and ergosterol biosynthesis under hypoxia and low iron conditions found at sites of human fungal infections.
Journal ArticleDOI
Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance.
TL;DR: Ergosterol, the major sterol of fungal membranes, is essential for developmental growth and the main target of antifungals that are currently used to treat fatal fungal infections as mentioned in this paper.
Journal ArticleDOI
Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi.
TL;DR: This review presents recent advances in the understanding of azole resistance mechanisms particularly in Aspergillus fumigatus and provides an overview of the genome sequences of non-fumicatus species, focusing on the proteins related to azole resistant mechanisms.
Journal ArticleDOI
Characterization of the sterol 14α‐demethylases of Fusarium graminearum identifies a novel genus‐specific CYP51 function
Jieru Fan,Jieru Fan,Martin Urban,Josie E. Parker,Helen C. Brewer,Steven L. Kelly,Kim E. Hammond-Kosack,Bart A. Fraaije,Xili Liu,Hans J. Cools +9 more
TL;DR: The first example of the functional diversification of a fungal CYP51 is presented, which reduces virulence on host wheat ears and increases the sensitivity of F. graminearum to the tested azoles.
References
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Journal ArticleDOI
Aspergillus fumigatus and Aspergillosis
TL;DR: This review focuses on the biology of A. fumigatus, one of the most ubiquitous of the airborne saprophytic fungi, and the diseases it causes, and discusses discussions of genomic and molecular characterization of the organism.
Aspergillus fumigatus and aspergillosis.
TL;DR: A review of the biology of Aspergillus fumigatus and the diseases it causes can be found in this article, where the authors discuss genomic and molecular characterization of the organism, clinical and laboratory methods available for the diagnosis of aspergillosis in immunocompetent and immunOCompromised hosts, identification of host and fungal factors that play a role in the establishment of the fungus in vivo, and problems associated with antifungal therapy.
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Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance
TL;DR: The mode of action of antifungals and their mechanisms of resistance are discussed, and an attempt is made to discuss the correlation between fungal and bacterial resistance.
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The induction and repression of nitrate reductase in the fungus Aspergillus nidulans.
TL;DR: The result of experiments indicate that the synthesis of nitrate reductase is induced by nitrate and repressed by ammonium, and no effect in vitro of ammonium could be found.
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A New Aspergillus fumigatus Resistance Mechanism Conferring In Vitro Cross-Resistance to Azole Antifungals Involves a Combination of cyp51A Alterations
Emilia Mellado,Guillermo Garcia-Effron,Laura Alcazar-Fuoli,Willem J. G. Melchers,Paul E. Verweij,Manuel Cuenca-Estrella,J. L. Rodriguez-Tudela +6 more
TL;DR: Only transformants which had incorporated the tandem repeat in the promoter of the cyp 51A gene and the L98H amino acid substitution exhibited similarly reduced patterns of susceptibility to all triazole agents and similarly increased levels of cyp51A expression, confirming that the combination of both alterations was responsible for the azole-resistant phenotype.