Journal ArticleDOI
Ethnic differences in the frequency of prostate cancer susceptibility alleles at SRD5A2 and CYP3A4.
Charnita Zeigler-Johnson,Amy H. Walker,B. Mancke,Elaine Spangler,Mohamed F Jalloh,S. McBride,Anne C. Deitz,S. B. Malkowicz,David Ofori-Adjei,Serigne Magueye Gueye,Timothy R. Rebbeck +10 more
Reads0
Chats0
TLDR
Ethnic differences in genotypes for genes associated with androgen metabolism including SRD5A2 and CYP3A4 also may exist, with Africans and African-Americans having the highest frequency of those alleles that have previously been associated with increased prostate cancer risk.Abstract:
Objectives: Ethnic differences in prostate cancer incidence are well documented, with African-Americans having among the highest rates in the world. Ethnic differences in genotypesread more
Citations
More filters
Journal ArticleDOI
Polymorphism of human cytochrome P450 enzymes and its clinical impact
TL;DR: Current pharmacogenetic knowledge on important human drug-metabolizing cytochrome P450s (CYPs) is highlighted to understand the large interindividual variability in drug clearance and responses in clinical practice and to improve the efficacy and safety of both prospective and currently available drugs.
Journal ArticleDOI
Assessing the function of genetic variants in candidate gene association studies.
TL;DR: New approaches to assessing functional significance of inherited genetic variation, which combine molecular genetics, epidemiology and bioinformatics, promise to enhance reproducibility and plausibility of associations between genotypes and disease.
Journal ArticleDOI
The epidemiology of sex steroid hormones and their signaling and metabolic pathways in the etiology of prostate cancer.
TL;DR: Data evaluating racial variation in sex steroid hormone pathways is described as a possible explanation for the notably higher risk of prostate cancer in African-American men compared to white or Asian men.
Journal ArticleDOI
CYP3A4 Polymorphisms—Potential Risk Factors for Breast and Prostate Cancer: A HuGE Review
TL;DR: The hypothesis that variant CYP3A4 may be involved in breast and prostate cancer and the notion that development of robust, conventional molecular epidemiologic case-control studies to address these questions, including gene-gene and gene-environment interactions, will be timely are supported.
Journal ArticleDOI
Explaining racial differences in prostate cancer in the United States: Sociology or biology?
TL;DR: Some thoughts are touched upon as to how to integrate the findings from sociological as well as biological studies and touch upon methods to reduce the disparate burden of prostate cancer among blacks in the United States.
References
More filters
Journal ArticleDOI
International trends and patterns of prostate cancer incidence and mortality
TL;DR: Large increases in both incidence and mortality rates of prostate cancer were seen for all countries, and increases were more pronounced in the United States, Canada, Australia, France and the Asian countries, while the increases in medium‐risk countries were moderate.
Journal ArticleDOI
Prospective Study of Sex Hormone Levels and Risk of Prostate Cancer
TL;DR: High levels of circulating testosterone and low levels of SHBG-both within normal endogenous ranges-are associated with increased risks of prostate cancer, and circulating levels of DHT and AAG do not appear to be strongly related to prostate cancer risk.
Journal ArticleDOI
Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4
TL;DR: It is determined that a single base change in the 5' flanking region of the CYP3A4 gene was associated with higher clinical stage and grade in men with prostate tumors.
Journal ArticleDOI
Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA
Nick M. Makridakis,Ronald K. Ross,Malcolm C. Pike,Laura E. Crocitto,Laurence N. Kolonel,C. Leigh Pearce,Brian E. Henderson,Jürgen K.V. Reichardt +7 more
TL;DR: The A49T variant of the SRD5A2 gene may be a significant contributor to the incidence of prostate cancer in African-American and Hispanic men in Los Angeles and the population attributable risk due to this aminoacid substitution for clinically significant disease is about 8% in both populations.
Related Papers (5)
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.
Peter M. Kuehl,Jiong Zhang,Yvonne S. Lin,Jatinder K. Lamba,Mahfoud Assem,John D. Schuetz,Paul B. Watkins,Ann K. Daly,Steven A. Wrighton,Stephen D. Hall,Patrick Maurel,Mary V. Relling,Cynthia Brimer,Kazuto Yasuda,Raman Venkataramanan,Stephen C. Strom,Kenneth E. Thummel,Mark S. Boguski,Erin G. Schuetz +18 more