Journal ArticleDOI
Etiology of Acute Undifferentiated Febrile Illness in the Amazon Basin of Ecuador
Stephen R. Manock,Kathryn H. Jacobsen,Narcisa Brito de Bravo,Kevin L. Russell,Monica Negrete,James G. Olson,José Luis Sánchez,Patrick J. Blair,Roger D. Smalligan,Brad K. Quist,Juan Freire Espín,Willan R. Espinoza,Fiona MacCormick,Lila C. Fleming,Tadeusz J. Kochel +14 more
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TLDR
A longitudinal observational study of 533 patients presenting to two hospitals in the Ecuadorean Amazon basin with acute undifferentiated febrile illness from 2001 through 2004 identified 3 cases of dengue fever, 2 of VEE, and 1 of Ilhéus, none of these pathogens, except for malaria, had previously been detected in the study area.Abstract:
We conducted a longitudinal observational study of 533 patients presenting to two hospitals in the Ecuadorean Amazon basin with acute undifferentiated febrile illness (AUFI) from 2001 through 2004. Viral isolation, reverse transcription-polymerase chain reaction (RT-PCR), IgM seroconversion, and malaria smears identified pathogens responsible for fever in 122 (40.1%) of 304 patients who provided both acute and convalescent blood samples. Leptospirosis was found in 40 (13.2%), malaria in 38 (12.5%), rickettsioses in 18 (5.9%), dengue fever in 16 (5.3%), Q fever in 15 (4.9%), brucellosis in 4 (1.3%), Ilheus infection in 3 (1.0%), and Venezuelan equine encephalitis (VEE), Oropouche, and St. Louis encephalitis virus infections in less than 1% of these patients. Viral isolation and RT-PCR on another 229 participants who provided only acute samples identified 3 cases of dengue fever, 2 of VEE, and 1 of Ilheus. None of these pathogens, except for malaria, had previously been detected in the study area.read more
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Journal ArticleDOI
Refining the global spatial limits of dengue virus transmission by evidence-based consensus
Oliver J. Brady,Peter W. Gething,Samir Bhatt,Jane P. Messina,John S. Brownstein,Anne G. Hoen,Catherine L. Moyes,Andrew Farlow,Thomas W. Scott,Thomas W. Scott,Simon I. Hay,Simon I. Hay +11 more
TL;DR: A contemporary global map of national-level dengue status is generated that assigns a relative measure of certainty and identifies gaps in the available evidence and provides a preliminary estimate of population at risk with an upper bound of 3.97 billion people.
Journal ArticleDOI
Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years
Paul R. Torgerson,José E. Hagan,Federico Costa,Juan Ignacio Calcagno,Michael J. Kane,Martha Sílvia Martinez-Silveira,Marga G. A. Goris,Claudia Stein,Albert I. Ko,Bernadette Abela-Ridder +9 more
TL;DR: The study findings indicate that highest burden estimates occur in resource-poor tropical countries, which include regions of Africa where the burden of leptospirosis has been under-appreciated and possibly misallocated to other febrile illnesses such as malaria.
Journal ArticleDOI
Arboviral Etiologies of Acute Febrile Illnesses in Western South America, 2000–2007
Brett M. Forshey,Carolina Guevara,V. Alberto Laguna-Torres,Manuel Cespedes,Jorge Vargas,Alberto Gianella,Efrain Vallejo,Cesar Madrid,Nicolas Aguayo,Eduardo Gotuzzo,Victor Suarez,Ana Morales,Luis Beingolea,Nora Reyes,Juan Perez,Monica Negrete,Claudio Rocha,Amy C. Morrison,Amy C. Morrison,Kevin L. Russell,Patrick J. Blair,James G. Olson,Tadeusz J. Kochel +22 more
TL;DR: The described arboviruses associated with acute undifferentiated febrile illness in participating clinics in four countries in South America and detailed epidemiological analysis in Iquitos, Peru are provided to provide a better understanding of the geographic range of arbaviruses in SouthAmerica.
Journal ArticleDOI
Brucellosis in low-income and middle-income countries.
TL;DR: Improvements in diagnostic options for resource-limited settings and stronger evidence for optimal therapy should enhance identification and treatment of human brucellosis, prevention of human disease through control in animals remains paramount.
Journal ArticleDOI
Epidemiology of Coxiella burnetii infection in Africa: a OneHealth systematic review.
Sky Vanderburg,Matthew P. Rubach,Joanna E.B. Halliday,Sarah Cleaveland,Elizabeth A. Reddy,John A. Crump +5 more
TL;DR: A systematic review of C. burnetii epidemiology in Africa from a “One Health” perspective to synthesize the published data and identify knowledge gaps and presents a real yet underappreciated threat to human and animal health throughout Africa.
References
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Journal ArticleDOI
Leptospirosis: a zoonotic disease of global importance
Ajay R. Bharti,Jarlath E. Nally,Jessica N. Ricaldi,Michael A. Matthias,Monica M. Diaz,Michael A. Lovett,Paul N. Levett,Robert H. Gilman,Michael R. Willig,Eduardo Gotuzzo,Joseph M. Vinetz +10 more
TL;DR: The completion of the genome sequence of Leptospira interrogans serovar lai, and other continuing leptospiral genome sequencing projects, promise to guide future work on the disease.
Journal ArticleDOI
Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction.
TL;DR: The accumulated data demonstrated that dengue viruses can be accurately detected and typed from viremic human serum samples.
Journal ArticleDOI
Spectrum of Disease and Relation to Place of Exposure among Ill Returned Travelers
David O. Freedman,Leisa H. Weld,Phyllis E. Kozarsky,Tamara L. Fisk,Rachel Robins,Frank von Sonnenburg,Jay S. Keystone,Prativa Pandey,Martin S. Cetron +8 more
TL;DR: When patients present to specialized clinics after travel to the developing world, travel destinations are associated with the probability of the diagnosis of certain diseases, and diagnostic approaches and empiric therapies can be guided by these destination-specific differences.
Journal ArticleDOI
Q Fever 1985-1998: Clinical and Epidemiologic Features of 1,383 Infections
Didier Raoult,Hervé Tissot-Dupont,Cédric Foucault,Joanny Gouvernet,Pierre E. Fournier,Emmanuelle Bernit,Andreas Stein,Meyer Nesri,Jean Robert Harlé,Pierre Jean Weiller +9 more
TL;DR: It is confirmed that chronic Q fever is mainly determined by host factors and demonstrate for the first time that host factors may also play a role in the clinical expression of acute Q fever.
Journal ArticleDOI
Epidemiologic features and clinical presentation of acute Q fever in hospitalized patients: 323 French cases.
HervéTissot Dupont,Didier Raoult,Philippe Brouqui,Francois Janbon,Dominique Peyramond,Pierre-Jean Weiller,Colette Chicheportiche,Meyer Nezri,Roland Poirier +8 more
TL;DR: In patients hospitalized for acute Q fever, there was a significantly higher sex ratio of males to females (2.3), which indicated that elder males, who are overrepresented due to the authors' recruitment bias, are more susceptible to C. burnetii infections.
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