Journal ArticleDOI
Eucaryotic DNA: organization of the genome for replication.
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This article is published in Cell.The article was published on 1978-10-01. It has received 420 citations till now. The article focuses on the topics: DNA replication & DNA repair.read more
Citations
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Isolation and characterisation of a yeast chromosomal replicator.
TL;DR: A yeast DNA sequence that behaves as a chromosomal replicator, ars1 (autonomously replicating sequence), has been isolated and allows autonomous replication of all co-linear DNA.
Journal ArticleDOI
Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells.
Dean A. Jackson,Ana Pombo +1 more
TL;DR: It is proposed that the coordinated replication of related groups of replicons, that form stable replicon clusters, contributes to the efficient activation and propagation of S phase in mammalian cells.
Journal ArticleDOI
Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy.
TL;DR: The results confirm the generally accepted theory that DNA is replicated coordinately in a specific temporal order during the S-phase and conclude that replicon clusters located in the same region are replicated in the the same relatively short period of time.
Journal ArticleDOI
A fixed site of DNA replication in eucaryotic cells
TL;DR: Electron microscopic autoradiography shows that, as with intact nuclei, sites of DNA replication are distributed throughout the nuclear matrix, and a fixed site of DNA synthesis is proposed in which DNA replication complexes are anchored to thenuclear matrix.
Journal ArticleDOI
Macromolecular domains within the cell nucleus.
TL;DR: A chronology of key events and events leading to the formation of the HJ-Uridine Incorporation, In Situ Nick Translation, and subsequent efforts to correct for these errors.
References
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Journal ArticleDOI
On the Regulation of DNA Replication in Bacteria
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Structure of chromatin.
TL;DR: The structure of nucleus and linker is described and the path followed by the DNA is described, revealing the arrangement of Histones and their role in theogenesis.
Journal ArticleDOI
Solenoidal model for superstructure in chromatin
J T Finch,A Klug +1 more
TL;DR: It is proposed that the x-ray reflections at orders of 110 A observed in chromatin originate in the spacing between turns of the solenoid rather than that between nucleosomes along the nucleofilament.
Journal ArticleDOI
The structure of histone-depleted metaphase chromosomes
J. R. Paulson,Ulrich K. Laemmli +1 more
TL;DR: A scaffolding model for metaphase chromosome structure is suggested in which a backbone of nonhistone proteins is responsible for the basic shape of metaphase chromosomes, and the scaffold organizes the DNA into loops along its length.
Journal ArticleDOI
On the mechanism of DNA replication in mammalian chromosomes
Joel A. Huberman,Arthur D. Riggs +1 more
TL;DR: It is found that the long fibers of which chromosomal DNA is composed are made up of many tandemly joined sections in each of which DNA is replicated at a fork-like growing point.
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On the mechanism of DNA replication in mammalian chromosomes
Joel A. Huberman,Arthur D. Riggs +1 more