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Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.

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TLDR
The study showed the clinical history screening test for AS to be moderately sensitive, but it might be better in clinical practice, and substitution of the Rome pain criterion for the New York pain criterion is proposed.
Abstract
The New York and the Rome diagnostic criteria for ankylosing spondylitis (AS) and the clinical history screening test for AS were evaluated in relatives of AS patients and in population control subjects. The New York criterion of pain in the (dorso) lumbar spine lacks specificity, and the chest expansion criterion is too insensitive. The Rome criterion of low back pain for more than 3 months is very useful. Our study showed the clinical history screening test for AS to be moderately sensitive, but it might be better in clinical practice. As a modification of the New York criteria, substitution of the Rome pain criterion for the New York pain criterion is proposed.

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The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility.

TL;DR: This is the first study that addresses IRAK1 rs3027898 polymorphism association with PsA susceptibility, but further studies could help to understand the extent of the proposed association.
Journal ArticleDOI

Fat metaplasia and backfill are key intermediaries in the development of sacroiliac joint ankylosis in patients with ankylosing spondylitis.

TL;DR: The hypothesis that SI joint ankylosis develops following repair of erosions is tested and that tissue characterized by fat metaplasia is a key intermediary step in this pathway is found.
Journal ArticleDOI

Levels of circulating Th17 cells and regulatory T cells in ankylosing spondylitis patients with an inadequate response to anti-TNF-α therapy.

TL;DR: The beneficial effect of anti-TNF- α therapy in AS might not only neutralize the effects of TNF-α but also down-regulate Th17 and Th17-related cytokines accompanied by up-regulating the Treg/TGF-β axis in responders.
Journal ArticleDOI

Frequency of osteopenia in adolescents with early-onset juvenile idiopathic arthritis: a long-term outcome study of one hundred five patients.

TL;DR: The development of low total-body BMC was related to the duration of active disease, disease severity, measures of bone resorption, weight, and height; and forty-one percent of the adolescents with early-onset JIA had low bone mass >11 years after disease onset.
References
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Journal ArticleDOI

The 1982 revised criteria for the classification of systemic lupus erythematosus

TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI

Preliminary criteria for the classification of systemic sclerosis (scleroderma)

TL;DR: A multicenter, ongoing study of early-diagnosed cases of systemic sclerosis and comparison patients with systemic lupus erythematosus, polymyositis/dermatomyositis, and Raynaud's phenomenon was conducted in order to develop classification criteria for systemic sclerosis.
Journal ArticleDOI

Clinical history as a screening test for ankylosing spondylitis.

TL;DR: A controlled study demonstrated that the clinical history may be sensitive and specific in the differential diagnosis of ankylosing spondylitis when reliance of five specific historic features is made.
Journal ArticleDOI

The Epidemiology of Chronic Rheumatism

TL;DR: The human hand is a fascinating subject, an actor of many roles and disguises: the man in miniature, revealing its owner's story, here is a book which sets out to teach us how best to examine it and is disappointing because it is only 50 per cent of the classic it might have been
Journal ArticleDOI

The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. A comparison of relatives of spondylitis patients with the general population.

TL;DR: The discriminatory value of the New York criterion of history of pain or the presence of pain at the dorsolumbar junction or in the lumbar spine was analyzed in the population and family studies and was found to be too nonspecific.
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