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Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.

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TLDR
The study showed the clinical history screening test for AS to be moderately sensitive, but it might be better in clinical practice, and substitution of the Rome pain criterion for the New York pain criterion is proposed.
Abstract
The New York and the Rome diagnostic criteria for ankylosing spondylitis (AS) and the clinical history screening test for AS were evaluated in relatives of AS patients and in population control subjects. The New York criterion of pain in the (dorso) lumbar spine lacks specificity, and the chest expansion criterion is too insensitive. The Rome criterion of low back pain for more than 3 months is very useful. Our study showed the clinical history screening test for AS to be moderately sensitive, but it might be better in clinical practice. As a modification of the New York criteria, substitution of the Rome pain criterion for the New York pain criterion is proposed.

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High serum vascular endothelial growth factor correlates with disease activity of spondylarthropathies.

TL;DR: Serum VEGF levels were not associated with presence of extra‐articular manifestations or syndesmophytes or with the grade of sacroiliitis, and therefore angiogenesis may play a role in SpA pathogenesis and may serve as a disease activity marker in SpAs.
Journal ArticleDOI

Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn’s disease

TL;DR: CARD15 variants were identified as genetic predictors of Crohn’s disease related sacroiliitis and an association was demonstrated between these polymorphisms and an extraintestinal manifestation of Cro bowel disease.
Journal ArticleDOI

Identifying Axial Spondyloarthritis in Dutch Primary Care Patients, Ages 20–45 Years, With Chronic Low Back Pain

TL;DR: To identify axial spondyloarthritis (SpA) in Dutch primary care patients with chronic low back pain (CLBP) and to design a simple referral model for general practitioners (GPs) that would identify patients at risk for axial SpA.
Journal ArticleDOI

Axial spondyloarthritis: a new disease entity, not necessarily early ankylosing spondylitis

TL;DR: New classification criteria for axial spondyloarthritis have been developed by as mentioned in this paper with the goal of increasing sensitivity of criteria for early inflammatory sorditis, but these criteria substantially increase heterogeneity of the resulting disease group, reducing their value in both research and clinical settings.
References
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Journal ArticleDOI

The 1982 revised criteria for the classification of systemic lupus erythematosus

TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI

Preliminary criteria for the classification of systemic sclerosis (scleroderma)

TL;DR: A multicenter, ongoing study of early-diagnosed cases of systemic sclerosis and comparison patients with systemic lupus erythematosus, polymyositis/dermatomyositis, and Raynaud's phenomenon was conducted in order to develop classification criteria for systemic sclerosis.
Journal ArticleDOI

Clinical history as a screening test for ankylosing spondylitis.

TL;DR: A controlled study demonstrated that the clinical history may be sensitive and specific in the differential diagnosis of ankylosing spondylitis when reliance of five specific historic features is made.
Journal ArticleDOI

The Epidemiology of Chronic Rheumatism

TL;DR: The human hand is a fascinating subject, an actor of many roles and disguises: the man in miniature, revealing its owner's story, here is a book which sets out to teach us how best to examine it and is disappointing because it is only 50 per cent of the classic it might have been
Journal ArticleDOI

The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. A comparison of relatives of spondylitis patients with the general population.

TL;DR: The discriminatory value of the New York criterion of history of pain or the presence of pain at the dorsolumbar junction or in the lumbar spine was analyzed in the population and family studies and was found to be too nonspecific.
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